Assay Device Sideways Ventilation Air Circulation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing assay devices face challenges with liquid control performance due to prolonged determination times, non-specific adsorption, and air gaps, which affect the accuracy and reliability of assays.
Innovation Solution
The assay device incorporates a microflow passage with an absorbing porous medium and a separating space, along with sideways ventilation passages for air circulation, to enhance liquid control and prevent non-specific adsorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If liquid is continuously fed through porous medium to ensure fluidity, then liquid flow is maintained, but determination time is prolonged and non-specific adsorption increases
Solution Approach 1:
The channel is divided into a first channel portion and a second channel portion, with the assay region positioned between them. Liquid flows through the first channel portion, passes over the assay region (without penetrating through porous medium), and then flows through the second channel portion. This segmentation allows liquid to be continuously supplied while reducing contact time with porous medium, thereby maintaining fluidity while shortening determination time and reducing non-specific adsorption.
2Strength
If pressure-sensitive adhesive or adhesive is used to form microflow passage, then structural integrity is achieved, but non-specific adsorption increases and liquid flow performance deteriorates
Solution Approach 1:
The invention extracts and eliminates the adhesive layer from the microflow passage structure. Instead of using pressure-sensitive adhesive or adhesive to form the microflow passage between layered structures, the passage is formed by direct structural integration of the layered porous media and barrier layers. This removal eliminates the source of non-specific adsorption while maintaining structural integrity through alternative design.
Solution Approach 2:
Different regions of the device are assigned different functional properties. The channel portions are designed with specific hydrophilic/hydrophobic characteristics to control liquid flow, while the assay region uses barrier layers with controlled permeability. This local differentiation allows structural integrity without relying on adhesive materials that cause non-specific adsorption.
3Device complexity
If layered porous media structure is used to form channel and assay region, then device complexity is reduced, but liquid flow performance deteriorates due to viscosity and friction
Solution Approach 1:
The invention applies local quality by differentiating the functional properties of different layers. The first and second layered porous media have controlled hydrophilic/hydrophobic characteristics that reduce friction and viscosity effects. The barrier layer between them provides controlled resistance. This localized functional differentiation maintains structural simplicity while optimizing liquid flow rate by minimizing unnecessary resistance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration improves liquid control performance by maintaining fluidity, reducing non-specific adsorption, and preventing air gaps, thereby enhancing the accuracy and reliability of assay results.
Implementation Method 1
two sideways ventilation passages being adjacent to both sides of the microflow passage, respectively in a width direction orthogonal to the flow direction, the two sideways ventilation passages being communicated with the microflow passage to allow air circulation
Implementation Method 2
The assay device of the lateral flow type is simply configured to move and operate the liquid using capillary phenomena of hydrophilic porous media, such as paper, cellulose membranes, and the like
Data Source
AI summary
An assay device allows enhancement of the liquid control performance. The assay device of the present invention includes a microflow passage 1, 31, 41 which allows flow of the liquid, an absorbing porous medium 2, 42 disposed at a distance from one end of the microflow passage, and a separating space 3, 43 disposed between the one end of the microflow passage and the absorbing porous medium. The assay device further includes two sideways ventilation passages 6, 46 which are adjacent to both sides of the microflow passage, respectively in the width direction orthogonal to the flow direction, the two sideways ventilation passages 6, 46 being communicated with the microflow passage to allow air circulation.