Astragalus Paecilomyces Fermentation for Hyperuricemia Treatment
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Solution Overview
Problem
The fermentation process of traditional Chinese medicine lacks consistency and control, making it difficult to guarantee safety, effectiveness, and stability, particularly in the production of Astragalus membranaceus-based medicaments for treating hyperuricemia and hypertriglyceridemia, as existing methods rely heavily on subjective experience and are not well-studied pharmacologically.
Innovation Solution
A novel fermentation method using Astragalus membranaceus powder as a substrate and Paecilomyces cicadae as a fermentation strain for solid-state fermentation, optimizing conditions such as temperature, humidity, and inoculation ratios to produce a fermentation fungal substance with enhanced polysaccharide content, which is then used to manufacture a medicament for treating hyperuricemia and/or hypertriglyceridemia.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional natural fermentation is used, then the process is simple and easy to operate, but the safety, effectiveness, stability and controllability are difficult to guarantee
Solution Approach 1:
The patent applies parameter changes by transitioning from conventional natural fermentation to modern controlled fermentation. Specific parameters including temperature (25-30°C), humidity (60-80%), pH value (3.5-5.5), and fermentation time (7-30 days) are precisely controlled to ensure reproducibility and reliability while maintaining operational simplicity through standardized protocols
Solution Approach 2:
The patent implements feedback mechanisms through real-time monitoring of fermentation parameters. The process includes continuous measurement of temperature, humidity, pH, and microbial growth, with automatic adjustment of conditions to maintain optimal fermentation environment, thereby ensuring safety, effectiveness, and stability
2Device complexity
If subjective experience is used to judge and control fermentation, then the process is simple, but consistency and controllability are poor
Solution Approach 1:
The patent replaces subjective human judgment with objective automated monitoring systems. Electronic sensors continuously measure fermentation parameters (temperature, humidity, pH, oxygen concentration) and provide digital data for precise control, eliminating variability introduced by subjective human assessment while maintaining relatively simple process equipment
Solution Approach 2:
The fermentation system is designed to self-regulate through automated feedback control. The monitoring and control system automatically adjusts environmental conditions based on real-time measurements, enabling the process to maintain optimal conditions without constant human intervention, thereby improving consistency and controllability
3Productivity
If bidirectional fermentation is used, then economic benefit and production cycle are improved, but the fermentation mechanism is more complex
Solution Approach 1:
The patent merges two fermentation processes into a bidirectional system where Astragalus membranaceus serves as both substrate and medium, and Paecilomyces cicadae acts as both fermenting microorganism and indicator organism. This integration allows simultaneous modification of medicinal components and production of active substances, improving economic benefit and shortening production cycle while managing complexity through unified process control
Solution Approach 2:
The patent applies multi-functionality by using Astragalus membranaceus for multiple purposes: as the medicinal substrate, as the growth medium for Paecilomyces cicadae, and as the source of polysaccharides and saponins. The system simultaneously achieves component modification, active substance production, and quality enhancement, thereby improving productivity while managing mechanism complexity through functional integration
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly increases polysaccharide content in the fermentation product, demonstrating improved efficacy in treating hyperuricemia and hypertriglyceridemia, as shown by reduced serum uric acid, urea nitrogen, creatinine, and triglyceride levels in rat models compared to traditional Astragalus membranaceus treatments.
Implementation Method 1
a fermentation process of medicinal materials in certain environmental conditions (for example, temperature, humidity, air, moisture, etc.) with the help of enzymes and microorganisms
Implementation Method 2
after purified or treated, the medicine is foamed to produce a yellow and white mildew coat through a catalytic decomposition of microorganisms and enzymes
Data Source
AI summary
Provided is a fermentation fungal substance of Astragalus membranaceus/Paecilomyces cicadae and its use. The fermentation fungal substance is obtained by solid fermentation with Astragalus membranaceus powder as a fermentation substrate and Paecilomyces cicadae as a fermentation strain. The fermentation fungal substance of Astragalus membranaceus/Paecilomyces cicadae in the present disclosure plays a significant role in treating hyperuricemia and/or hypertriglyceridemia.