Atomizer Rubber Plug Sealing for Leak-Free Drug Spraying

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Solution Overview

Problem

Current pre-filling syringes cause pain and injury during subcutaneous injections and are prone to leakage and overflow, necessitating a need for a more effective spraying assembly that maintains a vacuum state and prevents leakage during filling, transportation, and use.

Innovation Solution

A spraying assembly comprising an atomizer with an umbrella-shaped rubber plug and a sprayer with a nozzle, featuring a spiral boss and convex parts for sealing, which maintains a vacuum state and prevents leakage by using elastic materials like isobutylene isoprene rubber or TPU, and a push rod for controlled drug delivery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If subcutaneous injection is used for drug delivery, then drugs can be effectively administered, but it causes pain and injury to patients

Engineering Contradiction:
Improvepatient comfortVSAvoidpain and injury
Core Design Contradiction:
Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the traditional needle-based mechanical injection system with an atomization-based spray delivery system. The atomizer breaks the liquid medicine into fine droplets that can be inhaled or sprayed onto mucous membranes, eliminating the need for needle penetration and thereby removing pain and injury while maintaining effective drug delivery

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent utilizes phase transition of the liquid medicine from a continuous liquid state to a dispersed aerosol state through atomization. This phase change allows the medicine to be delivered in a non-invasive manner through inhalation or spray application, avoiding the harmful effects of subcutaneous injection while preserving therapeutic efficacy

Inventive Principle:
Principle #36Phase transitions

2Ease of manufacture

If the needle tube inner cavity is open to prevent vacuum state, then filling is easier, but leakage and overflow occur during transportation and storage

Engineering Contradiction:
Improvefilling processVSAvoidleakage prevention
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent applies local quality by creating a vacuum-sealed environment specifically within the needle tube inner cavity while leaving the rest of the system open. The rubber plug with precise sealing structure maintains vacuum state locally in the medicine storage area, preventing leakage during transportation while allowing controlled delivery during use

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The patent implements preliminary action by establishing the vacuum state in the needle tube inner cavity before the actual drug delivery process. The pre-filled syringe is sealed and vacuumed during manufacturing, creating a stable, leak-proof environment that maintains medicine integrity throughout storage and transportation until the moment of use

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The assembly ensures a vacuum state in the needle tube, preventing leakage and overflow, and delivers drugs in a mist form, reducing patient discomfort and ensuring reliable drug delivery.

Implementation Method 1

it is very important to keep the needle tube inner cavity of the spraying device in vacuum state

Methodology Applied
Scientific EffectVacuum: Vacuum

Implementation Method 2

The rubber plug is made of elastic material

Methodology Applied
Scientific EffectElasticity: Elasticity

Implementation Method 3

An atomizer inner cavity and an atomizer channel located below the atomizer inner cavity are provided in the atomizer

Methodology Applied
Scientific EffectAtomization: Aerosol

Data Source

PatentUS12576219B2Spraying assembly
Publication Date: 2026.03.17 WUXI NEST BIOTECHNOLOGY CO LTD
  • US12576219B2 patent drawing
  • US12576219B2 patent drawing
  • US12576219B2 patent drawing

AI summary

A spraying assembly, including an atomizer, a sprayer and a rubber plug, and an atomizer inner cavity and an atomizer channel located below the atomizer inner cavity are provided in the atomizer, an atomizer end (130) is included in a lower part of the atomizer, and a side wall of the atomizer end is provided with at least one opening; the rubber plug is located at a bottom end of the atomizer inner cavity, an upper end of the rubber plug is provided with an umbrella-shaped boss, an annular cavity is formed between a lower end of the rubber plug and an inner wall of the atomizer, the rubber plug is provided with at least one longitudinal notch along a circumferential direction, and the bottom end of the atomizer inner cavity is provided with at least one notch; the sprayer includes a nozzle.