Atopic Dermatitis Prevention Regimen Using Skin Barrier Composition

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Solution Overview

Problem

Current treatments for atopic dermatitis in newborns are ineffective in preventing the onset of the condition, with moisturizers showing mixed results and no unanimous consensus on their use, highlighting a need for a more effective and well-tolerated skin treatment regimen.

Innovation Solution

A window of opportunity skin treatment regimen and composition that combines specific ingredients such as caprylic/capric triglyceride, Avena Sativa Kernel Flour, and ceramide 3 to improve skin barrier function, have a probiotic effect, act as antioxidants, and stimulate ceramide and fatty acid production, applied from birth to eight weeks of age.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If moisturizers are used to treat newborn skin, then skin hydration is improved, but the effectiveness in preventing atopic dermatitis is inconsistent and uncertain

Engineering Contradiction:

Improveeffectiveness in preventing atopic dermatitisVSAvoidtreatment regimen complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The treatment is applied during the 'window of opportunity' from birth to 8 weeks, before atopic dermatitis develops. This preliminary action during the critical period when skin barrier is forming prevents the disease onset rather than treating it after symptoms appear, resolving the inconsistency in preventive effectiveness

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The invention changes the timing parameter (applying treatment during the specific window of birth to 8 weeks) and composition parameters (specific ratios of ceramides, cholesterol, and free fatty acids). These parameter changes transform the unreliable moisturizing approach into a reliable prevention strategy by targeting the critical developmental period of the skin barrier

Inventive Principle:

Principle #35Parameter changes

2Object-affected harmful factors

If the skin barrier is strengthened to prevent allergen penetration, then protection against atopic dermatitis is improved, but the treatment must be applied during a specific limited time window

Engineering Contradiction:

Improveallergen penetrationVSAvoidtreatment time window

Core Design Contradiction:

Object-affected harmful factorsVSLoss of time

Solution Approach 1:

The treatment is applied preliminarily during the window of opportunity (birth to 8 weeks) when the skin barrier is naturally developing. By acting during this critical formation period, the treatment establishes strong barrier function before allergens can penetrate, making the time limitation a strategic advantage rather than a disadvantage

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The treatment performs preliminary anti-action by strengthening the skin barrier before the harmful effect (allergen penetration) can occur. By pre-establishing the protective barrier during the window of opportunity, the treatment prevents the subsequent harmful effect of allergen penetration that would trigger atopic dermatitis

Inventive Principle:

Principle #9Preliminary anti-action

3Reliability

If a combination of multiple ingredients is used to improve skin barrier function, then protection is enhanced, but the composition complexity increases

Engineering Contradiction:

Improveskin barrier protectionVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The invention uses a composite material approach by combining ceramides, cholesterol, and free fatty acids in specific ratios that mimic the natural skin barrier composition. This composite formulation enhances barrier protection more effectively than single ingredients while maintaining biocompatibility and reducing formulation complexity through nature-based design

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The combination of ingredients serves multiple functions simultaneously: ceramides provide barrier structure, cholesterol regulates fluidity, and free fatty acids maintain pH balance. This multi-functionality achieves comprehensive skin barrier protection with a unified formulation, reducing the need for separate treatment components

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The regimen significantly reduces the incidence of atopic dermatitis by 50% at six months and maintains this reduction at twelve months, improving skin hydration and reducing permeability, thereby preventing skin dryness and allergen penetration.

Implementation Method 1

caprylic/capric triglyceride, preferably from about 0.0% to about 1.0%

Methodology Applied

Scientific EffectEmollient effect:

Implementation Method 2

Avena Sativa Kernel Flour, and ceramide 3 to improve skin barrier function, have a probiotic effect, act as antioxidants

Methodology Applied

Scientific EffectAntioxidant effect: Oxidation

Implementation Method 3

ceramide 3 to improve skin barrier function... improving skin hydration and reducing permeability

Methodology Applied

Scientific EffectBarrier function:

Implementation Method 4

stimulate ceramide and fatty acid production

Methodology Applied

Scientific EffectStimulation of lipid synthesis:

Data Source

PatentUS20230309921A1Window of Opportunity Skin Treatment Regimen and Composition for Preventing the Onset of or Treating Atopic Dermatitis

Publication Date: 2023.10.05 KENVUE BRANDS LLC

AI summary

A window of opportunity skin treatment regimen and composition for preventing the onset of or treating atopic dermatitis is disclosed.