Atractylenolide-I Personal Care Composition for Hyperpigmentation

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Solution Overview

Problem

Current personal care compositions do not effectively address hyperpigmentation, a significant skin imperfection caused by sunlight, despite incorporating various botanical extracts, indicating a need for enhanced formulations.

Innovation Solution

A personal care composition combining Atractylenolide-I and a hydroxy fatty acid, with specific weight ranges, to provide synergistic benefits in reducing hyperpigmentation and improving skin appearance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If various botanical extracts are incorporated into personal care compositions, then the composition provides natural skin benefits, but the effectiveness against hyperpigmentation is insufficient

Engineering Contradiction:
Improveeffectiveness against hyperpigmentationVSAvoidformulation complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines Atractylenolide-I (a potent tyrosinase inhibitor) with hydroxy fatty acids in a synergistic formulation. This merging of specific active ingredients with natural botanical extracts achieves enhanced anti-hyperpigmentation effectiveness while maintaining the desired natural skin benefits, resolving the contradiction between reliability and formulation complexity.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite personal care composition that integrates Atractylenolide-I, hydroxy fatty acids, and botanical extracts. This composite formulation leverages the complementary properties of each component to deliver superior hyperpigmentation reduction while preserving the natural skin benefits, effectively addressing the technical contradiction.

Inventive Principle:
Principle #40Composite materials

2Reliability

If Atractylenolide-I is used to reduce melanin content, then hyperpigmentation is reduced, but the formulation requires precise concentration control

Engineering Contradiction:
Improvehyperpigmentation reductionVSAvoidconcentration control
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The patent specifies precise concentration ranges for Atractylenolide-I (0.01-15% w/w) and hydroxy fatty acids (0.1-20% w/w) to optimize hyperpigmentation reduction while managing manufacturing precision requirements. This parameter optimization ensures reliable effectiveness while providing clear guidance for consistent formulation manufacturing.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If natural ingredients are used for skin benefits, then overall skin health is improved, but the ability to effectively address hyperpigmentation is limited

Engineering Contradiction:
Improvehyperpigmentation treatment efficacyVSAvoidskin imperfections
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent introduces Atractylenolide-I and hydroxy fatty acids as intermediary active ingredients that bridge between natural botanical extracts and effective hyperpigmentation treatment. These intermediaries enhance the tyrosinase inhibition capability while working synergistically with natural ingredients, thereby effectively addressing hyperpigmentation without compromising overall skin health benefits.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively inhibits melanin content, thereby reducing hyperpigmentation and enhancing skin appearance, as demonstrated by its application in topical formulations.

Implementation Method 1

Atractylenolide-I has been known for its skin whitening effect through the inhibition of tyrosinase

Methodology Applied
Scientific EffectTyrosinase inhibition: Enzyme

Data Source

PatentEP4188318B1A personal care composition comprising atractylenolide-i or a source thereof
Publication Date: 2024.03.06 UNILEVER IP HLDG BV
  • EP4188318B1 patent drawing

AI summary

The present invention relates to a personal care composition. In particular, the present invention relates to a personal care composition for providing benefits against hyperpigmentation. Accordingly, the present invention discloses a personal care composition comprising: a. Atractylenolide-I or a source of Atractylenolide-I; and b. A hydroxy fatty acid having the number of carbon atom from 12 to 20.