Attenuated Pathogenic Bacteria for Gastrointestinal Colonization
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Solution Overview
Problem
Current treatments for infections caused by pathogens like Salmonella, Clostridium, and Escherichia coli often result in severe side effects and antibiotic resistance, necessitating an effective, side-effect-free alternative for treating gastrointestinal tract infections in animals.
Innovation Solution
A microbial composition comprising attenuated forms of pathogenic bacteria that can colonize the gastrointestinal tract, exerting an antagonistic effect against specific pathogens by secreting molecules that disrupt cell growth, nutrient availability, and membrane integrity, thereby reducing the harmful effects of native bacteria.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If anti-infective medications (antibiotics) are administered to treat infections, then the infection is treated, but severe side effects occur and antibiotic resistance develops
Solution Approach 1:
The patent uses attenuated forms of pathogenic bacteria (harmful organisms) converted into beneficial probiotics that colonize the GI tract and provide protective effects against infections, thereby converting harmful factors into beneficial ones
Solution Approach 2:
The patent introduces probiotic bacteria as intermediary organisms that mediate between the host animal and pathogenic bacteria, providing protective effects through competitive exclusion and immune modulation without directly using antibiotics
2Reliability
If conventional treatments are used for gastrointestinal infections, then infections are targeted, but resistance and side effects limit long-term effectiveness
Solution Approach 1:
The patent administers probiotics in advance to colonize the gastrointestinal tract before pathogenic infections occur, establishing protective colonization that prevents or reduces the severity of subsequent infections
Solution Approach 2:
The patent establishes continuous protective colonization through probiotic administration and maintenance, creating sustained beneficial effects in the gastrointestinal tract that provide ongoing protection against infections
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The attenuated bacterial composition effectively reduces infection severity and incidence in animals by competing with native pathogens, eliciting an immune response and providing protection without the need for antibiotics, as demonstrated in examples involving chickens and piglets.
Implementation Method 1
having an ability to colonize the gastrointestinal tract
Implementation Method 2
exerting an antagonistic effect against a bacterium... by secreting molecules that disrupt cell growth
Data Source
AI summary
Provided are microbial compositions comprising at least one attenuated form of a pathogenic bacterium having an ability to colonize at least one organ of the gastrointestinal tract of an animal, such as an attenuated form of a bacterium having an antagonistic effect against a bacterium selected from the group consisting of Salmonella enteritidis, Salmonella enterica, Salmonella typhimurium, lostridium difficile, Clostridium perfringens, Escherichia coli, Campylobacter spp., Listeria monocytogenes, Yersinia enterocolitica and combinations thereof. Also provided are animal feeds comprising such compositions, preparations for in-ovo injection comprising such compositions and methods of treatment using such compositions.