Therapeutic Auditory Neuromodulation With Dynamic EEG-Band Waveforms

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Solution Overview

Problem

Existing medical treatments for physiological and psychological disorders, including auditory neuromodulation, often provide temporary relief due to patient accommodation, necessitating a need for long-term therapeutic solutions that selectively influence the hypothalamic-pituitary-adrenal axis to modulate neurotransmitter release.

Innovation Solution

Therapeutic auditory stimulation using non-linear, multi-parametric sound waveforms corresponding to EEG frequency bands, including delta, theta, alpha, beta 1, beta 2, and gamma bands, to modulate neural activity and influence the HPA axis, providing long-term treatment for disorders such as anxiety, autism, and diabetes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If standard auditory neuromodulation is used, then temporary symptom relief is achieved, but patient accommodation occurs leading to loss of therapeutic effect

Engineering Contradiction:

Improvetherapeutic effect persistenceVSAvoidduration of symptom relief

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent implements dynamic parameter modulation where the auditory stimulation parameters (frequency, amplitude, duration) are continuously varied over time rather than remaining constant. This dynamic approach prevents the nervous system from adapting to a fixed stimulus pattern, thereby maintaining therapeutic effectiveness over extended periods. The system adjusts parameters based on real-time feedback or predetermined protocols to ensure ongoing therapeutic impact.

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The invention systematically changes multiple stimulation parameters including frequency, amplitude, pulse width, and inter-stimulus intervals according to specific protocols. These parameter variations are designed to target different neural populations and prevent accommodation. The patent describes specific parameter ranges and modulation patterns that optimize therapeutic effect while minimizing adaptation.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If medical treatments are used to treat physiological and psychological disorders, then symptoms are relieved, but systemic side effects occur

Engineering Contradiction:

Improvesymptom relief effectivenessVSAvoidsystemic side effects

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent replaces pharmacological chemical interventions with physical auditory stimulation. Instead of using medications that act systemically through the bloodstream, the invention uses sound waves to directly modulate neural activity in specific brain regions. This substitution eliminates the systemic side effects associated with drugs while maintaining therapeutic effectiveness through targeted neuromodulation of the HPA axis and neurotransmitter systems.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If surgical treatments are used, then long-term therapeutic effect is achieved, but invasive and destructive procedures are required

Engineering Contradiction:

Improvelong-term therapeutic effectVSAvoidinvasiveness and tissue damage

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The invention substitutes invasive surgical mechanical procedures with non-invasive acoustic stimulation. Instead of physically altering brain tissue through surgery, the patent uses auditory stimuli to modulate neural circuitry and neurotransmitter release. This approach achieves long-term therapeutic effects by inducing neuroplastic changes and regulating the HPA axis without any physical intrusion into the body, thereby eliminating surgical risks and tissue damage.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The non-linear sound waveforms effectively reduce symptoms of these disorders by altering EEG band contributions, leading to persistent therapeutic mental or behavioral changes without systemic side effects.

Implementation Method 1

sound may be used to encode neural signals for therapeutic effect. Such auditory neuromodulation has been used to treat disorders in humans.

Methodology Applied

Scientific EffectAuditory neuromodulation:

Implementation Method 2

Counteracting tinnitus by acoustic coordinated reset neuromodulation.

Methodology Applied

Scientific EffectAcoustic coordinated reset neuromodulation:

Data Source

PatentUS12564350B2Methods and systems for therapeutic neuromodulation

Publication Date: 2026.03.03 BIOSENSOR INC

AI summary

Systems, methods and computer-readable media are disclosed for providing therapeutic auditory stimulation. Consistent with disclosed embodiments, a system for providing therapeutic auditory stimulation may comprise a diagnostic unit that computes an EEG spectral density of a patient and a heart rate spectral density of a patient and provides values for one or more EEG frequency bands and one or more heart rate frequency bands. The system may also comprise a therapy unit that generates, based on the provided values, one or more stimulation waveforms corresponding to one or more of the EEG frequency bands and provides the stimulation waveforms for therapeutic auditory stimulation. The stimulation waveforms may comprise audible carrier frequencies modulated by signals with frequencies that vary exponentially with time. The EEG frequency bands may comprise the delta, theta, alpha, beta 1, beta 2, and gamma EEG frequency bands.