Closed-loop Auditory Stimulation for Sleep Onset

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Solution Overview

Problem

Current non-drug approaches to sleep onset insomnia, such as behavioral and cognitive methods, are inadequate in efficiently helping individuals transition into a sleep stage, as they lack a systematic and responsive mechanism to modulate brain activity for faster sleep onset.

Innovation Solution

A system comprising sensors and processors that determine spectral parameters of brain activity to control a stimulus source, adjusting the intensity of auditory stimuli based on these parameters to promote a shift from higher to lower frequency brain activity, mimicking natural sleep onset physiological changes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If behavioral and cognitive approaches are used to help sleep onset insomnia, then non-drug treatment is provided, but the efficiency of transitioning into sleep stage is insufficient

Engineering Contradiction:
Improvesleep transition efficiencyVSAvoidtime to fall asleep
Core Design Contradiction:
ProductivityVSLoss of time

Solution Approach 1:

The system continuously monitors brain activity through sensors and adjusts stimulus delivery in real-time based on spectral parameters. The closed-loop feedback mechanism modifies stimulus intensity and timing according to the subject's actual brain state, enabling dynamic adaptation to accelerate sleep transition more effectively than static behavioral techniques

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system manipulates stimulus parameters (intensity, frequency, timing) based on spectral parameters derived from brain activity. By changing stimulus parameters in response to measured brain state changes, the system creates an active feedback loop that accelerates the natural sleep transition process

Inventive Principle:
Principle #35Parameter changes

2Ease of operation

If conventional non-drug approaches are used, then sleep hygiene recommendations and relaxation training are provided, but they lack a systematic mechanism to modulate brain activity

Engineering Contradiction:
Improvesystematic modulation of brain activityVSAvoidcomplexity of brain activity modulation
Core Design Contradiction:
Ease of operationVSDevice complexity

Solution Approach 1:

The system provides real-time feedback about brain activity through spectral parameter analysis and adjusts stimulus delivery accordingly. This closed-loop feedback creates a systematic mechanism for modulating brain activity by continuously adapting to the subject's actual neural state

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system replaces conventional mechanical/behavioral sleep hygiene techniques with an automated sensor-based system that electronically monitors and responds to brain activity, substituting manual relaxation practices with objective physiological monitoring and automated stimulus delivery

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Productivity

If stimulus intensity is adjusted based on spectral parameters, then sleep transition is accelerated, but real-time processing requirements increase

Engineering Contradiction:
Improvesleep onset speedVSAvoidprocessing power required
Core Design Contradiction:
ProductivityVSPower

Solution Approach 1:

The system extracts specific spectral parameters (power in frequency bands) from the complex brain activity signal. By focusing processing on these key spectral features rather than analyzing the entire raw signal, the system reduces computational burden while maintaining effective sleep transition acceleration

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The system divides the brain activity signal into frequency bands and processes each band separately to determine spectral parameters. This segmentation approach allows parallel processing and reduces the complexity of real-time analysis by breaking down the overall processing task into smaller, manageable frequency-specific operations

Inventive Principle:
Principle #1Segmentation

Data Source

PatentEP2950867B1Brain-wave based closed-loop sensory stimulation to induce sleep
Publication Date: 2019.05.01 KONINKLIJKE PHILIPS NV
  • EP2950867B1 patent drawingFigure 1
  • EP2950867B1 patent drawingFigure 2~3
  • EP2950867B1 patent drawingFigure 4

AI summary

Systems and methods for delivering stimuli to a subject that prompt the subject to fall asleep use multiple parameters that are based on measured signals related to a patient's brain activity, for example obtained through electroencephalography (EEG). The parameters indicate amplitude in different frequency bands, e.g. high-frequency brain activity and low-frequency brain activity. A stimulus, e.g. auditory stimulus, is delivered to the subject such that the intensity of the stimulus is adjusted based on (changes in) the multiple parameters.