Aurantiamide Acetate for Low-Side-Effect Hypertension Control
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Solution Overview
Problem
Current antihypertensive drugs for hypertension treatment have significant side effects, leading to patient dissatisfaction and discontinuation of medication, and they do not effectively reduce cardiovascular morbidity and complications.
Innovation Solution
Aurantiamide acetate is used to regulate endothelium-mediated vascular function, increasing erythrocyte deformability and blood fluidity, thereby reducing blood pressure and vessel pressure without common side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stress or pressure
If conventional antihypertensive drugs are used to lower blood pressure, then blood pressure is reduced, but significant side effects occur leading to patient dissatisfaction and discontinuation
Solution Approach 1:
The patent uses a different chemical compound (aurantiamide acetate) with different pharmacological properties compared to conventional antihypertensive drugs. This parameter change in the active ingredient results in blood pressure reduction without the typical side effects of conventional drugs such as ACE inhibitors, ARBs, beta-blockers, or calcium channel blockers.
Solution Approach 2:
The patent employs a natural product derivative (aurantiamide acetate from Portulaca oleracea) that acts as a short-acting, effective antihypertensive agent without cumulative side effects, replacing long-term conventional medication regimens that cause progressive adverse effects.
2Duration of action of stationary object
If conventional antihypertensive drugs are used for long-term treatment, then blood pressure control is achieved, but patient compliance decreases due to side effects
Solution Approach 1:
The patent describes a treatment approach where patients experience beneficial effects without adverse reactions, enabling them to continue treatment voluntarily. The absence of side effects allows patients to maintain compliance without external monitoring or motivation, effectively making the treatment self-sustaining.
3Stress or pressure
If conventional antihypertensive drugs are used to lower blood pressure, then vascular pressure is reduced, but cardiovascular morbidity and complications are not effectively reduced
Solution Approach 1:
The patent replaces the mechanical/physiological approach of conventional drugs (blocking receptors, inhibiting enzymes) with a natural product that improves endothelium-mediated vascular function. This substitution results in both blood pressure reduction and improved cardiovascular outcomes through enhanced vascular health.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Aurantiamide acetate effectively lowers blood pressure with minimal side effects, enhances endothelium-mediated vascular function, and reduces hypertension complications by improving erythrocyte deformability and blood fluidity.
Implementation Method 1
enhances endothelium-mediated vascular function, and reduces hypertension complications by improving erythrocyte deformability and blood fluidity
Data Source
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AI summary
The present invention relates to the use of aurantiamide acetate in the treatment of hypertension. According to the present invention, by means of aurantiamide acetate's restoration of endothelium-mediated vascular function in hypertension, it can be used especially in the preparation of blood pressure lowering drugs or health care products. An effective treatment and administration of aurantiamide acetate in patients with hypertension provides an increase in erythrocyte deformability by means of an antihypertensive drug with low side effects for the effective treatment of hypertension patients with aurantiamide acetate, especially through the endothelium-mediated vascular function-regulating effect of aurantiamide acetate and the reduction of pressure in the vessels by increasing blood fluidity.