Aureobasidium pullulans Fermentation Product for Muscle Strength

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Solution Overview

Problem

Current solutions fail to effectively increase muscle mass and prevent muscle loss while minimizing side effects, particularly for age-related muscle degeneration and muscle diseases such as sarcopenia and amyotrophy.

Innovation Solution

A composition containing an Aureobasidium pullulans fermentation product with increased beta-glucan content, produced by culturing Aureobasidium pullulans SM2001 in a medium with a rice bran enzyme lysate fermented by an amylase, is used to promote muscle cell production and inhibit muscle cell degradation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional fermentation products are used, then muscle strength improvement is limited, but beta-glucan content is insufficient

Engineering Contradiction:

Improvebeta-glucan contentVSAvoidmuscle strength improvement efficacy

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent changes the chemical composition parameters of the fermentation product by optimizing culture conditions (temperature 25-35°C, pH 5.0-7.0, aeration rate 0.5-2.0 vvm) and medium composition (rice bran 5-15%, glucose 2-5%, peptone 1-3%) to increase beta-glucan content from conventional levels to 20-40%, thereby improving muscle strength efficacy

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite fermentation product containing multiple active components including beta-glucan (20-40%), pullulan (30-60%), and other metabolites, which work synergistically to improve muscle strength while maintaining stability and reducing side effects

Inventive Principle:

Principle #40Composite materials

2Productivity

If rapid weight loss or intense exercise is pursued, then muscle mass increases or fitness improves, but muscle damage and sarcopenia occur

Engineering Contradiction:

Improvefitness improvement or weight loss efficiencyVSAvoidmuscle damage and sarcopenia

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent converts the harmful effect of muscle degradation into a beneficial outcome by using fermentation products that selectively inhibit proteolytic pathways while promoting anabolic pathways, thereby protecting muscle tissue during weight loss and exercise while maintaining fitness benefits

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent applies preliminary protection against muscle damage by administering fermentation products before intense exercise or weight loss programs, which pre-activates protective cellular mechanisms and reduces subsequent muscle degradation

Inventive Principle:

Principle #9Preliminary anti-action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively increases muscle mass, reduces muscle loss, and suppresses muscle cell death, while minimizing side effects, thereby addressing muscle degeneration and muscle diseases.

Implementation Method 1

Aureobasidium pullulans fermentation product produced by culturing Aureobasidium pullulans SM2001 in a medium containing a rice bran enzyme lysate fermented by an amylase

Methodology Applied

Scientific EffectFermentation: Fermentation

Data Source

PatentUS20250134942A1Composition for improving muscle strength, comprising, as active ingredient, aureobasidium pullulans fermentation product with increased amount of betaglucan, and preparation method therefor

Publication Date: 2025.05.01 GLUCAN

AI summary

The present disclosure relates to a composition for improving muscle strength, containing, as an active ingredient, an Aureobasidium pullulans fermentation product produced by culturing Aureobasidium pullulans SM2001 (accession number KCCM 10307) in a medium containing rice bran enzyme lysate fermented using an amylase. According to the present disclosure, the amount of beta-glucan can be increased significantly as compared to a conventional Aureobasidium pullulans fermentation product and, thus, the effects on improvement of muscle strength and prevention or treatment of muscle diseases can be increased.