Aureobasidium pullulans extract for skin barrier repair

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Solution Overview

Problem

Fine dust causes premature aging, skin dryness, and potential skin cancer by penetrating the skin and damaging its barrier function, with existing solutions lacking effective protection against these effects.

Innovation Solution

A composition utilizing an Aureobasidium pullulans strain, its lysate, culture, or extract as an active ingredient to enhance skin barrier function by promoting keratinocyte differentiation and tight junction marker expression, thereby improving skin damage caused by fine dust.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional skincare products are used, then general skin protection is provided, but they fail to effectively protect against fine dust penetration and damage

Engineering Contradiction:

Improveskin barrier protection effectivenessVSAvoidfine dust penetration damage

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses Aureobasidium pullulans culture extract as an intermediary substance that mediates between the skin and fine dust environment. The extract contains bioactive compounds that form a protective interface, preventing fine dust from directly penetrating skin barriers while maintaining skin physiology. This resolves the contradiction by introducing a third substance that actively counters the harmful effects without compromising skin function.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the chemical composition parameters of the skincare product by incorporating specific microbial culture extracts (Aureobasidium pullulans). This alters the functional properties of the product, giving it enhanced abilities to prevent fine dust penetration and repair skin damage. The parameter change transforms a conventional product into one with specialized protection capabilities.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If the skin barrier function is enhanced through keratinocyte differentiation, then skin protection and moisturizing are improved, but the complexity of the composition increases

Engineering Contradiction:

Improveskin barrier functionVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The Aureobasidium pullulans culture extract serves multiple functions simultaneously: it promotes keratinocyte differentiation, enhances tight junction formation, provides moisturizing effects, and protects against fine dust. This multi-functionality resolves the contradiction by achieving multiple protective outcomes through a single compositional element, thereby enhancing skin barrier function without proportionally increasing complexity.

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Adaptability or versatility

If microbial resources are utilized for skin protection, then environment-friendly and sustainable solutions are provided, but the effectiveness against fine dust damage is unproven

Engineering Contradiction:

Improveenvironmental sustainabilityVSAvoidfine dust protection effect

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent employs Aureobasidium pullulans, a microorganism that naturally produces protective compounds (pullulan, melanin) for its own survival in harsh environments. By utilizing this self-service protective mechanism of the microorganism and applying it to skin protection, the patent achieves both environmental sustainability and proven effectiveness. The microorganism's innate protective capabilities are harnessed to counter fine dust damage, resolving the contradiction between sustainability and effectiveness.

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively increases keratin 1 and claudin 4 expression levels, enhancing skin moisturizing, anti-aging, and wrinkle-improving effects, thus improving skin barrier function and addressing fine dust-induced damage.

Implementation Method 1

promoting the expression of keratinocyte differentiation markers and granular layer tight junction markers

Methodology Applied

Scientific EffectKeratinocyte differentiation:

Implementation Method 2

granular layer tight junction markers expression

Methodology Applied

Scientific EffectTight junction formation:

Implementation Method 3

increases keratin 1 and claudin 4 expression levels

Methodology Applied

Scientific EffectGene expression regulation:

Implementation Method 4

skin-moisturizing effects

Methodology Applied

Scientific EffectMoisturizing:

Data Source

PatentUS11504409B2Composition for improving skin damage by fine dust comprising culture or its extract of <i>Aureobasidium pullulans</i>

Publication Date: 2022.11.22 AMOREPACIFIC CORP

AI summary

Disclosed in the present disclosure is a composition for improving skin damage caused by fine dust, which contains an Aureobasidium pullulans strain; a lysate thereof; a culture thereof; or an extract of the strain, the lysate or the culture as an active ingredient, and the composition has an effect of promoting the expression of keratinocyte differentiation markers and granular layer tight junction markers, thereby enhancing the skin barrier function and having skin-moisturizing, anti-aging and wrinkle-suppressing effects, and, thus, has an excellent effect in terms of improving skin damage caused by fine dust.