Autobiotic Composition Combining Prebiotic and Postbiotic Components
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Solution Overview
Problem
Existing treatments for excessive intestinal permeability and gut dysbiosis, such as probiotics, can be ineffective or harmful, and there is a need for compositions that promote a healthy gut microbiome without causing side effects, especially in individuals with weakened immune systems.
Innovation Solution
Autobiotic compositions combining prebiotic and postbiotic components to enhance the body's ability to create its own healthy microbiome, optionally including a seedbiotic to support the microbiome's self-optimization, without relying on exogenous probiotics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If exogenous probiotics are administered to treat gut dysbiosis and excessive intestinal permeability, then the intention is to restore healthy microbiome balance, but the treatment can be ineffective or harmful especially in individuals with weakened immune systems
Solution Approach 1:
The patent applies the self-service principle by providing the body with prebiotic and postbiotic components that enable the endogenous production of beneficial microbiome elements. Rather than introducing exogenous probiotics that may cause harm, the composition allows the body's own cellular mechanisms to generate healthy microbiome components, making the system self-sufficient and avoiding immune system conflicts
Solution Approach 2:
The patent uses prebiotics and postbiotics as intermediary substances that facilitate the body's endogenous production of beneficial microbiome elements. These intermediaries support the growth and function of native beneficial bacteria without introducing external probiotics, thereby mediating between the need for microbiome restoration and the risk of probiotic-related harm
2Duration of action of stationary object
If the body's endogenous ability to create healthy microbiome is enhanced through prebiotic and postbiotic components, then sustainable long-term improvement is achieved, but the complexity of the composition increases
Solution Approach 1:
The patent merges prebiotic and postbiotic components into a single integrated autobiotic composition. The prebiotic component supports the growth of beneficial bacteria while the postbiotic component provides metabolic byproducts that further nurture the microbiome. This combination creates a synergistic effect that sustains microbiome health long-term while maintaining formulation simplicity
3Ease of operation
If probiotics are administered to restore microbiome balance, then the intention is to improve digestive health, but the treatment can aggravate the condition in cases of dysbiosis due to the vicious cycle of stress and malnutrition
Solution Approach 1:
The autobiotic composition empowers the body to self-correct microbiome imbalances by providing the necessary prebiotic and postbiotic building blocks. This eliminates the need for complex probiotic regimens and allows the body's natural healing mechanisms to operate effectively, breaking the vicious cycle of stress and malnutrition associated with dysbiosis
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The autobiotic compositions promote a sustainable and long-term improvement in digestive health, mood, and cognition by supporting the body's natural microbiome optimization, minimizing side effects and addressing intestinal permeability and dysbiosis effectively.
Implementation Method 1
The prebiotic component may be a digestion-resistant substrate that is fermentable by microorganisms of the large intestine
Implementation Method 2
The postbiotic component is an exogenous form of fermentation byproducts generated by the microbiota in a healthy colon
Data Source
AI summary
A method of administering an autobiotic composition that includes a prebiotic component and postbiotic component. The prebiotic component is a substance resistant to digestion in the stomach and small intestine and selectively fermentable by microorganisms in the large intestine. The postbiotic component is a short-chain fatty acid, such as butyric acid, lactic acid, succinic acid, or salt or ester thereof. The prebiotic component is advantageously delivered to the stomach and/or small intestine and the postbiotic is advantageously delivered to the large intestine. A seedbiotic component may form part of or be co-administered with the autobiotic composition. Enzymes may form part of or be co-administered with the autobiotic composition to enhance digestion of the prebiotic in the stomach and intestine and/or increase microbiome health. An exogenous ketone body component may form part of or be co-administered with the autobiotic composition.