Autoimmune Treatment Regimen With Staggered Vaccination Timing

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Solution Overview

Problem

Current treatments for autoimmune disorders using immunosuppressive drugs pose a high risk of severe infections and adverse events, particularly viral and bacterial infections, due to the suppression of the immune system, and vaccinations are challenging to administer safely during ongoing immunosuppressive treatment.

Innovation Solution

A novel treatment regimen that integrates immunosuppressive therapy with a staggered vaccination schedule to minimize immune suppression risks, ensuring a safe interval before and after immunosuppressive treatment to allow for effective immune response.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If immunosuppressive drugs are administered to treat autoimmune disorders, then therapeutic efficacy is improved, but the risk of infections and adverse events increases

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidrisk of infections

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent administers vaccinations before initiating immunosuppressive therapy to ensure the patient's immune system can mount an adequate response. This preliminary action addresses the contradiction by establishing protective immunity prior to the period of immunosuppression, thereby reducing infection risk while maintaining therapeutic efficacy

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent implements periodic vaccinations at predetermined time points during the course of immunosuppressive therapy. This periodic approach allows the immune system to recover between vaccination doses, enabling effective immune response while minimizing continuous suppression, thus balancing therapeutic efficacy with infection risk reduction

Inventive Principle:

Principle #19Periodic action

2Reliability

If vaccinations are administered during immunosuppressive treatment, then protection against infections is improved, but the immune response to vaccination is reduced

Engineering Contradiction:

Improveprotection against infectionsVSAvoidimmune response

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent schedules vaccinations to occur before immunosuppressive therapy begins or during periods when the immune system is not severely suppressed. This timing strategy ensures adequate immune response by avoiding the nadir of lymphocyte counts, while still providing protective immunity

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent plans vaccination timing in advance to coincide with periods of relatively higher immune function during immunosuppressive therapy. By cushioning the vaccination schedule against periods of severe immunosuppression, the patent maintains both immune response capacity and infection protection

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

Data Source

PatentUS12539329B2Treatment regimen for the treatment of autoimmune disorders

Publication Date: 2026.02.03 MERCK PATENT GMBH

AI summary

A novel treatment regimen is provided for the treatment of autoimmune disorders. Said novel treatment regimen provides for an efficacious treatment of autoimmune disorders with an advantageous safety profile and/or a high quality of life for the patient. Said novel treatment regimen provides for an advantageous benefit-risk ratio for patients endangered by the risk of infections.