Automated Chromatograph Apparatus for Preparative Separation and Analysis
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Solution Overview
Problem
Conventional methods for preparative separation and analysis of target components in chromatograph apparatuses require significant time and labor, involving multiple steps such as setting conditions, checking separation results, and performing detailed analyses.
Innovation Solution
A chromatograph apparatus with a preparative separation device, a conditions setter for both preparative and analysis conditions, an executer for preparative separation, and an analysis executer that automates the process from sample preparation to analysis, reducing the need for manual intervention and data retrieval.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If manual operation is used for preparative separation and analysis, then the user can control each step, but the time and labor required increase significantly
Solution Approach 1:
The chromatograph apparatus performs preparative separation and analysis operations automatically without requiring continuous user intervention. The system executes preparative separation based on set conditions, automatically identifies target components, and performs detailed analysis without manual data retrieval or condition re-setting, thereby reducing time and labor while maintaining operational control
Solution Approach 2:
The user sets preparative separation and analysis conditions in advance before starting the operation. The system stores these conditions and automatically retrieves and applies them during the preparative separation and subsequent analysis processes, eliminating the need for manual condition re-setting and reducing operational time
2Reliability
If manual checking of separation results is required, then the user can verify specific information, but the process becomes more complex and time-consuming
Solution Approach 1:
The system automatically retrieves identification information of the preparative separation container from the preparative separation results and provides this feedback to the analysis execution unit. This automatic information feedback eliminates the need for manual checking and verification by the user, reducing process complexity while maintaining reliability through automated data accuracy
Solution Approach 2:
The system merges the preparative separation result retrieval function with the analysis condition execution function. The identification information from preparative separation is automatically integrated and used to set analysis conditions without requiring separate manual verification steps, thereby simplifying the overall process while ensuring data reliability
3Manufacturing precision
If separate setting of preparative separation and analysis conditions is required, then each condition can be optimized, but the number of operation steps increases
Solution Approach 1:
The chromatograph apparatus integrates multiple functions into a unified system that handles both preparative separation and detailed analysis. The system uses a single set of pre-configured conditions that govern both operations, allowing the same apparatus to perform multiple functions (preparative separation, target component identification, and detailed analysis) without requiring separate condition setting procedures for each step, thereby optimizing both separation and analysis while reducing operation steps
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The apparatus significantly reduces the time and labor required for preparative separation and analysis by automating the setting and execution of conditions, allowing for continuous operation from preparative separation to detailed analysis without manual intervention.
Implementation Method 1
a liquid sample is introduced into a column in the liquid chromatograph, and a target component contained in the liquid sample is separated from the other components by the column
Implementation Method 2
the separated target component is injected into a different column called an analysis column and subjected to separation under analysis conditions
Data Source
AI summary
A sample container (172) holding a sample and a preparative separation container (173) for containing a target component obtained from the sample by preparative separation can be arranged in a preparative separation device (17). A preparative-separation-and-analysis conditions setter (42) allows users to set a preparative separation condition for the target component and an analysis condition for the target component after the preparative separation. A preparative separation executer (43) collects a sample from the sample container, separates the target component contained in the sample, and puts the separated target component into the preparative separation container according to the preparative separation condition after the preparative separation condition and the analysis condition are set. An analysis executer (44) collects the target component from the preparative separation container and performs an analysis of the target component according to the analysis condition, after the preparative separation of the target component.