Automated cryogenic storage system

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Solution Overview

Problem

Current cryogenic storage systems require manual handling of sample racks, which is inefficient and prone to errors, as they need to be manually removed from the cryogenic environment for access or addition of samples, leading to potential temperature fluctuations and increased operational risks.

Innovation Solution

An automated cryogenic storage system with a freezer and retrieval system that includes a drive system, insulating sleeve, and rack puller, allowing for automated rotation and elevation of sample racks through a port for easy access, maintaining the cryogenic environment and enabling automated sample retrieval and storage.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If manual handling of sample racks is used, then operational simplicity is maintained, but efficiency and precision deteriorate

Engineering Contradiction:
Improvesample retrieval efficiencyVSAvoidsystem complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The system enables automated self-service operation where the retrieval system independently rotates the rack carrier, positions selected racks, and transfers them through the port without requiring manual intervention inside the cryogenic environment, thereby improving efficiency while maintaining operational simplicity from the user perspective

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent replaces manual mechanical handling with an automated retrieval system that uses a motorized rack carrier rotation mechanism and automated rack positioning system, substituting human labor with mechanical automation to improve productivity

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Ease of operation

If manual removal of racks from cryogenic environment is required, then access flexibility is improved, but temperature stability deteriorates

Engineering Contradiction:
Improvesample access flexibilityVSAvoidcryogenic environment stability
Core Design Contradiction:
Ease of operationVSTemperature

Solution Approach 1:

The automated retrieval system acts as an intermediary mechanism that enables sample access without requiring direct manual entry into the cryogenic environment. The system rotates and positions racks externally, transferring them through a sealed port, thus maintaining temperature stability while providing operational flexibility

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The system segments the access process into external rack positioning and internal rack transfer operations. The rack carrier rotation and rack positioning occur externally without opening the cryogenic environment, separating the access function from the temperature-stable storage environment

Inventive Principle:
Principle #1Segmentation

3Measurement precision

If automated retrieval system is implemented, then handling precision is improved, but system complexity increases

Engineering Contradiction:
Improverack positioning precisionVSAvoidretrieval system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system incorporates sensors and control mechanisms that provide feedback on rack carrier rotation position and rack location, enabling precise positioning through automated control. This feedback mechanism ensures accurate rack alignment and transfer while managing system complexity through intelligent control

Inventive Principle:
Principle #23Feedback

4Ease of operation

If racks are manually accessed through port opening, then operational simplicity is maintained, but operational safety deteriorates

Engineering Contradiction:
Improveoperational simplicityVSAvoidoperational safety
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The automated retrieval system serves as an intermediary that performs all hazardous operations outside the cryogenic environment. The system rotates racks, positions them, and transfers them through the sealed port, eliminating the need for operators to manually handle racks in the cryogenic zone, thus improving safety while maintaining operational simplicity

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system ensures efficient, automated, and precise handling of sample racks within the cryogenic environment, reducing human error and maintaining consistent low temperatures, thus enhancing storage integrity and operational safety.

Implementation Method 1

The insulating sleeve houses the selected sample rack above the port

Methodology Applied
Scientific EffectThermal insulation: Thermal Insulation

Data Source

PatentUS11414268B2Automated cryogenic storage system
Publication Date: 2022.08.16 AZENTA US INC
  • US11414268B2 patent drawing
  • US11414268B2 patent drawing
  • US11414268B2 patent drawing

AI summary

An automated cryogenic storage system includes a freezer and an automation system to provide automated transfer of samples to and from the freezer. The freezer includes a bearing and a drive shaft though the freezer, the drive shaft being coupled to a rack carrier inside the freezer and adapted to be coupled to a motor. The automation module includes a rack puller that is automatically positioned above an access port of the freezer. The rack puller engages with a sample rack within the freezer, and elevates the rack into an insulating sleeve external to the freezer. From the insulating sleeve, samples can be added to and removed from the sample rack before it is returned to the freezer.