Automated Injection Compounding System for Personalized Medicine
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Solution Overview
Problem
Current pharmaceutical administration methods, particularly oral administration, face challenges with bioavailability issues due to incomplete absorption and first-pass metabolism, necessitating personalized injection treatments that can vary significantly from patient to patient, especially for vitamins and other agents like insulin and growth hormones.
Innovation Solution
An automated system for compounding pharmaceutical agents for injection treatments, which includes a housing with inventory chambers for single-use capsules, mechanisms for selecting and transferring pharmaceutical agents to a product container under positive or negative pressure, and automated disposal of used capsules, enabling personalized and efficient preparation of injectable combinations in a physician's office or clinic.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If oral administration of pharmaceutical agents is used, then ease of administration is improved, but bioavailability and treatment efficacy deteriorate due to incomplete absorption and first-pass metabolism
Solution Approach 1:
The patent replaces the oral mechanical ingestion system with an automated injection system that uses mechanical needles and syringes to deliver pharmaceutical agents directly into the patient's body, bypassing the gastrointestinal tract and achieving 100% bioavailability while maintaining ease of administration through automation
Solution Approach 2:
The automated injection system performs the administration function automatically without requiring manual preparation or administration by healthcare providers, enabling self-service operation while ensuring precise delivery of the pharmaceutical agent
2Reliability
If personalized formulations of pharmaceutical agents are developed for each patient, then treatment efficacy is improved, but device complexity and manufacturing complexity increase
Solution Approach 1:
The system segments the pharmaceutical agent storage into multiple separate compartments or reservoirs, each containing a different agent or concentration, allowing the automated system to mix and deliver personalized formulations by combining specific segments according to the patient's treatment plan
Solution Approach 2:
The system enables dynamic adjustment of pharmaceutical agent parameters such as concentration, volume, and combination ratios through automated control mechanisms, allowing personalized formulations to be prepared on-demand without requiring complex manual compounding procedures
3Reliability
If injectable combinations of pharmaceutical agents are administered, then treatment efficacy is improved, but risk of contamination and infection increases
Solution Approach 1:
The system employs disposable needles, syringes, and/or mixing chambers that are discarded after a single use, eliminating the risk of cross-contamination between patients and ensuring sterility without requiring complex sterilization procedures or maintenance of reusable components
Solution Approach 2:
The automated system introduces sterile barriers and sealed connection mechanisms as intermediaries between the pharmaceutical agent reservoirs and the patient, preventing contamination during the transfer and mixing of multiple agents while maintaining treatment efficacy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This system allows for safe and efficient personalized medicine delivery, improving treatment outcomes for patients by ensuring effective doses of vitamins, growth hormones, and other agents, and can be used for both injection and topical treatments, enhancing bioavailability and treatment efficacy.
Implementation Method 1
transferred a controlled quantity of the predetermined pharmaceutical agent with direct fluid communication from each selected capsule to a product container such as a product vial or a syringe under positive or negative pressure
Implementation Method 2
transferred a controlled quantity of the predetermined pharmaceutical agent with direct fluid communication from each selected capsule to a product container such as a product vial or a syringe under positive or negative pressure
Data Source
AI summary
An automated system (100) for compounding pharmaceutical agents for injection treatment of a patient includes a housing (110) enclosing an interior space; an inventory structure (130) having a plurality of chambers (131) for individually holding one or more pharmaceutical agent—containing single use capsules (102), wherein each capsule has a volume capacity of from about 0.1 to about 10.0 mL liquid; means (140) for selecting capsules in accordance with predetermined pharmaceutical agents contained in said capsules; means (150) for moving the selected capsules to a processing area; means (165,166) for sequentially transferring a controlled quantity of the predetermined pharmaceutical agent with direct fluid communication from each selected capsule to a product container under positive or negative pressure; and means (151) for automatically discarding spent capsules from which the pharmaceutical agents have been removed after a single use.