Automated Mouse Blood Sampling With Tail Restraint
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Solution Overview
Problem
Current methods of mouse blood sampling require manual handling, leading to physical strain and contamination due to accidental tail hair staining during tail clipping.
Innovation Solution
A full-automatic mouse blood sampling apparatus with a tail restraining assembly, tail cutting and cleaning assembly, compression hemostasis, and a tail releasing mechanism, allowing for hands-free operation and preventing tail hair contamination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Extent of automation
If manual tail clipping is performed, then blood sampling can be completed, but physical strain increases and contamination occurs due to accidental tail hair staining
Solution Approach 1:
The apparatus performs blood sampling automatically without requiring manual tail clipping. The system includes an automated tail restraining mechanism and blood collection system that operates independently, eliminating the need for human hands to handle the tail during the critical sampling phase.
Solution Approach 2:
The patent replaces manual mechanical tail clipping with an automated system. The tail restraining assembly uses mechanical clamps and positioning mechanisms to hold the tail in place, while the blood collection system uses automated pipetting or capillary action to collect blood, eliminating manual intervention.
2Reliability
If manual tail restraint is used, then tail control is achieved, but contamination occurs due to tail hair staining with blood
Solution Approach 1:
The patent extracts the tail from the general body structure and implements a specialized tail restraining assembly with dedicated clamps and positioning mechanisms. This separate tail handling system prevents the tail from contacting the operator's hands during blood collection, eliminating contamination risk.
Solution Approach 2:
The apparatus introduces an intermediary tail restraining assembly between the operator and the mouse tail. This intermediate mechanism holds the tail in place during blood collection, preventing direct contact and thus preventing contamination of the tail hair with blood.
3Productivity
If manual operation is used, then flexibility is maintained, but productivity decreases due to time-consuming manual handling
Solution Approach 1:
The apparatus performs preliminary actions by pre-positioning the mouse in the holder and pre-adjusting the tail restraining assembly before blood collection begins. The automated system is prepared in advance with the tail already restrained and the blood collection pathway established, eliminating time-consuming manual adjustments during the sampling process.
Solution Approach 2:
The automated blood sampling system maintains continuous useful action without interruption. The tail restraining assembly holds the tail in the optimal position throughout the entire blood collection process, and the automated blood collection system continuously collects blood without manual intervention, maximizing sampling efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables fully automated mouse blood sampling, reducing physical strain and preventing contamination by restraining the tail and cleaning the cut-off end, while ensuring efficient hemostasis and easy mouse release.
Implementation Method 1
a compression hemostasis assembly disposed on the second end of the first connecting plate
Implementation Method 2
a first electric telescopic rod fixedly disposed on the carrier frame, an output end of the first electric telescopic rod being fixedly connected to the first end of the first connecting plate
Implementation Method 3
a rotating plate disposed inside the blood sampling port, a front end of the rotating plate being rotationally connected to a side wall of the blood sampling port, and a first drive assembly configured to drive the rotating plate to rotate
Data Source
AI summary
A full-automatic mouse blood sampling apparatus includes: a carrier frame; a mouse holding tube disposed on the top of the carrier frame and having a first notch formed on the top of the mouse holding tube; a first carrier plate disposed inside the rear end of the mouse holding tube, a blood sampling port is provided in a top surface of the first carrier plate, a rotating plate is disposed inside the blood sampling port, a front end of the rotating plate is rotationally connected to a side wall of the blood sampling port, a tail restraining assembly is disposed on a top surface of the rotating plate, and a first drive assembly is disposed below the first carrier plate; a tail cutting assembly disposed on the rear side of the mouse holding tube; and a centrifuge tube disposed below a rear end of the rotating plate.