Automated Olfactory Detection System for Sequential Sample Analysis
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current animal-based olfactory detection systems lack real-time evaluation and efficiency in presenting and analyzing multiple olfactory samples, relying on human interpretation and manual interaction, which can lead to reduced accuracy and increased costs.
Innovation Solution
A system utilizing processing circuitry and structural elements like conveyors or carousels to present a sequence of olfactory samples one at a time to trained rats, with sensors and machine-readable codes for real-time calculation and display of sensitivity and selectivity, and automatic detection of animal responses using proximity detectors or video monitoring.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If multiple olfactory samples are presented simultaneously to the animal using plural holders, then the detection throughput is increased, but the measurement precision and reliability of individual sample detection deteriorates due to inability to track which specific sample triggered the animal's response
Solution Approach 1:
The system segments the presentation of multiple samples by using a mechanical conveyor that delivers samples sequentially through a single aperture, one at a time. This segmentation in time allows precise tracking of which sample the animal is responding to, while still achieving high throughput through automated continuous presentation. The aperture acts as a gate that isolates the animal's olfactory input to a single sample source at any moment.
Solution Approach 2:
A mechanical intermediary system (conveyor with aperture) is introduced between the multiple samples and the animal. This intermediary controls the timing and delivery of samples, ensuring that only one sample reaches the animal at a time while maintaining a queue of multiple samples ready for presentation. The intermediary resolves the contradiction by decoupling the plurality of samples from the singularity of the animal's sensory input.
2Device complexity
If human handlers manually interpret animal responses to determine target odor presence, then the system complexity is reduced, but the measurement precision and objectivity of detection deteriorates
Solution Approach 1:
The system enables self-service detection by automatically recording and interpreting the animal's responses without human intervention. Sensors detect the animal's behavior (such as nose movements or position changes) and automatically log which samples triggered responses. The system self-evaluates detection accuracy by comparing against known positive and negative samples, eliminating the need for human handlers to interpret responses while maintaining high measurement precision.
Solution Approach 2:
The patent replaces the mechanical system of human observation and interpretation with electronic sensing and automated data processing. Sensors substitute for human eyes and brains in detecting and interpreting animal responses. This substitution eliminates human subjectivity and fatigue-related errors while maintaining system simplicity through automated workflows that require minimal human input.
3Ease of operation
If a single-hole enclosure is used for early training of the animal, then the ease of operation during training is improved, but the productivity during testing deteriorates due to need for multiple enclosures and complex sample presentation
Solution Approach 1:
The system dynamically adapts the sample presentation configuration based on the operational phase. During training, the conveyor presents samples sequentially through the single aperture in a controlled manner suitable for learning. During testing, the same single aperture receives samples from a high-speed conveyor that can present multiple samples rapidly. The dynamic flexibility of the system allows the same enclosure to serve both training and testing functions efficiently, eliminating the need for multiple enclosures.
Solution Approach 2:
The single-hole enclosure with integrated conveyor system serves multiple functions: it can be used for both training and testing phases, and the same aperture handles both simple training samples and high-speed test samples. The conveyor system itself is universal, capable of adjusting presentation speed and sample flow based on whether the animal is being trained or tested. This multi-functionality eliminates the need for separate enclosures for training and testing.
4Measurement precision
If real-time calculation and display of sensitivity and selectivity is implemented, then the measurement precision and feedback for performance evaluation is improved, but the device complexity increases
Solution Approach 1:
The system implements real-time feedback by continuously calculating sensitivity (percentage of correct positive detections) and selectivity (percentage of correct negative detections) as samples are presented and animal responses are recorded. These metrics are displayed immediately, allowing operators to monitor animal performance during both training and testing phases. The feedback loop enables real-time adjustment of training protocols or testing parameters to optimize detection performance.
Solution Approach 2:
The patent replaces manual calculation and evaluation methods with automated electronic computation. A computer system automatically tracks animal responses, identifies which samples were positive or negative, and calculates sensitivity and selectivity metrics in real-time. This substitution of mechanical calculation with electronic processing achieves high measurement precision while managing complexity through software automation rather than complex hardware.
Data Source
Figure 1
Figure 2
Figure 3
AI summary
Animal-based olfactory detection of one or more target substances in a sequence of filters includes providing one or more enclosures each housing an animal, each enclosure including a sample presenting structure via which only a single olfactory sample is presented to the animal at any given time, presenting samples of the sequence of filters to the animal via the structure, one at a time, and generating an output indication of olfactory detection of target substances in the sequence of filters.