Automated Olfactory Detection System for Sequential Sample Analysis

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Solution Overview

Problem

Current animal-based olfactory detection systems lack real-time evaluation and efficiency in presenting and analyzing multiple olfactory samples, relying on human interpretation and manual interaction, which can lead to reduced accuracy and increased costs.

Innovation Solution

A system utilizing processing circuitry and structural elements like conveyors or carousels to present a sequence of olfactory samples one at a time to trained rats, with sensors and machine-readable codes for real-time calculation and display of sensitivity and selectivity, and automatic detection of animal responses using proximity detectors or video monitoring.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If multiple olfactory samples are presented simultaneously to the animal using plural holders, then the detection throughput is increased, but the measurement precision and reliability of individual sample detection deteriorates due to inability to track which specific sample triggered the animal's response

Engineering Contradiction:
Improvedetection throughputVSAvoidsample identification accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The system segments the presentation of multiple samples by using a mechanical conveyor that delivers samples sequentially through a single aperture, one at a time. This segmentation in time allows precise tracking of which sample the animal is responding to, while still achieving high throughput through automated continuous presentation. The aperture acts as a gate that isolates the animal's olfactory input to a single sample source at any moment.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

A mechanical intermediary system (conveyor with aperture) is introduced between the multiple samples and the animal. This intermediary controls the timing and delivery of samples, ensuring that only one sample reaches the animal at a time while maintaining a queue of multiple samples ready for presentation. The intermediary resolves the contradiction by decoupling the plurality of samples from the singularity of the animal's sensory input.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Device complexity

If human handlers manually interpret animal responses to determine target odor presence, then the system complexity is reduced, but the measurement precision and objectivity of detection deteriorates

Engineering Contradiction:
Improvesystem simplicityVSAvoiddetection accuracy
Core Design Contradiction:
Device complexityVSMeasurement precision

Solution Approach 1:

The system enables self-service detection by automatically recording and interpreting the animal's responses without human intervention. Sensors detect the animal's behavior (such as nose movements or position changes) and automatically log which samples triggered responses. The system self-evaluates detection accuracy by comparing against known positive and negative samples, eliminating the need for human handlers to interpret responses while maintaining high measurement precision.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent replaces the mechanical system of human observation and interpretation with electronic sensing and automated data processing. Sensors substitute for human eyes and brains in detecting and interpreting animal responses. This substitution eliminates human subjectivity and fatigue-related errors while maintaining system simplicity through automated workflows that require minimal human input.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Ease of operation

If a single-hole enclosure is used for early training of the animal, then the ease of operation during training is improved, but the productivity during testing deteriorates due to need for multiple enclosures and complex sample presentation

Engineering Contradiction:
Improvetraining simplicityVSAvoidtesting throughput
Core Design Contradiction:
Ease of operationVSProductivity

Solution Approach 1:

The system dynamically adapts the sample presentation configuration based on the operational phase. During training, the conveyor presents samples sequentially through the single aperture in a controlled manner suitable for learning. During testing, the same single aperture receives samples from a high-speed conveyor that can present multiple samples rapidly. The dynamic flexibility of the system allows the same enclosure to serve both training and testing functions efficiently, eliminating the need for multiple enclosures.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The single-hole enclosure with integrated conveyor system serves multiple functions: it can be used for both training and testing phases, and the same aperture handles both simple training samples and high-speed test samples. The conveyor system itself is universal, capable of adjusting presentation speed and sample flow based on whether the animal is being trained or tested. This multi-functionality eliminates the need for separate enclosures for training and testing.

Inventive Principle:
Principle #6Universality (Multi-functionality)

4Measurement precision

If real-time calculation and display of sensitivity and selectivity is implemented, then the measurement precision and feedback for performance evaluation is improved, but the device complexity increases

Engineering Contradiction:
Improveperformance evaluation accuracyVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system implements real-time feedback by continuously calculating sensitivity (percentage of correct positive detections) and selectivity (percentage of correct negative detections) as samples are presented and animal responses are recorded. These metrics are displayed immediately, allowing operators to monitor animal performance during both training and testing phases. The feedback loop enables real-time adjustment of training protocols or testing parameters to optimize detection performance.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent replaces manual calculation and evaluation methods with automated electronic computation. A computer system automatically tracks animal responses, identifies which samples were positive or negative, and calculates sensitivity and selectivity metrics in real-time. This substitution of mechanical calculation with electronic processing achieves high measurement precision while managing complexity through software automation rather than complex hardware.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Data Source

PatentEP3583379B1An improved system, method and computer program product for animal-based olfactory detection
Publication Date: 2024.11.20 ICTS EURO SAS
  • EP3583379B1 patent drawingFigure 1
  • EP3583379B1 patent drawingFigure 2
  • EP3583379B1 patent drawingFigure 3

AI summary

Animal-based olfactory detection of one or more target substances in a sequence of filters includes providing one or more enclosures each housing an animal, each enclosure including a sample presenting structure via which only a single olfactory sample is presented to the animal at any given time, presenting samples of the sequence of filters to the animal via the structure, one at a time, and generating an output indication of olfactory detection of target substances in the sequence of filters.