Automated Sequential Incubation in a Continuous Fluid Circuit
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Solution Overview
Problem
Current biological fluid processing systems require separation stages between successive incubation stages or manual steps for additional incubation, which are inefficient for sequential incubation processes.
Innovation Solution
A fluid processing system with a disposable circuit and reusable device that automates sequential incubation stages using a controller to actuate pumps, clamps, and a spinning membrane separator, allowing for a first and second incubation stage to be executed without intervening steps.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Extent of automation
If manual steps or separation stages are used between incubation stages, then system complexity is reduced, but productivity and automation are worsened
Solution Approach 1:
The patent combines multiple incubation stages into a single continuous automated process within one fluid circuit. The incubation loop integrates the separator, in-process container, and tubing to enable sequential incubation without requiring separate manual steps or additional separation stages between incubation periods, thereby increasing automation while managing system complexity through integrated design
Solution Approach 2:
The fluid circuit components, particularly the separator and tubing system, serve multiple functions: they enable both separation operations and sequential incubation operations. The incubation loop utilizes existing circuit elements for dual purposes, allowing the system to perform automated sequential incubation without adding dedicated separate components for each function
2Productivity
If separation stages are required between incubation stages, then processing reliability is improved, but loss of time and productivity worsen
Solution Approach 1:
The patent implements continuous automated processing where the incubation loop maintains uninterrupted fluid flow and processing operations. The system executes first and second incubation stages sequentially without stopping or requiring manual intervention between stages, eliminating idle time and maintaining continuous productive action throughout the process
Solution Approach 2:
The system is pre-configured with the incubation loop and automated control sequences before processing begins. The controller is programmed with the sequence of operations for multiple incubation stages, and all necessary circuit components are in place and connected, allowing the process to proceed immediately without setup time or intervening manual steps between incubation stages
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables automated, efficient processing of biological fluids with sequential incubation stages, producing high-quality incubation products without manual intervention.
Implementation Method 1
Separation devices may separate the biological fluid based on centrifugal separation and/or, as described below, membrane separation
Implementation Method 2
Separation devices may separate the biological fluid based on centrifugal separation and/or, as described below, membrane separation
Data Source
AI summary
A fluid processing method and an associated system are provided. The fluid processing method includes a first and second incubation stage which are performed sequentially without any intermediate steps. The fluid processing method creates a second incubation fluid product from a biological fluid.