Automated Single-Use Filtration for Large-Volume Process Control
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Solution Overview
Problem
Current disposable filtration devices are limited to smaller filter elements and lack integration into automated processes, necessitating a need for a ready-to-use, partially or fully automated filtration device suitable for large-scale operations, especially in commercial pharmaceutical production.
Innovation Solution
An automated disposable filtration device equipped with sensors and control devices connected to an external monitoring and control system, allowing for continuous process parameter monitoring and control, including flow, pressure, and venting, to facilitate partially or fully automated filtration processes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If disposable filtration devices are used for large-volume filtration processes, then filtration capacity is improved, but automation capability deteriorates
Solution Approach 1:
The disposable filtration device is designed with multiple integrated functions including filtration, venting, sensor integration, and control capabilities. The device can handle both small and large volume filtrations, and supports both manual and automated operation modes, making it universally applicable across different filtration scenarios and eliminating the need for separate automated systems.
2Area of stationary object
If filter size is increased for large-volume filtration, then filtration area is improved, but device complexity deteriorates
Solution Approach 1:
The filter element is divided into multiple smaller filter units arranged in a grid pattern within the disposable device. Each filter unit can be independently manufactured and then assembled into the complete filtration device. This segmentation allows for large total filtration area while maintaining manufacturing simplicity and enabling modular assembly without increasing overall device complexity.
3Ease of operation
If manual operation is used for disposable filtration devices, then ease of operation is improved, but process reliability deteriorates
Solution Approach 1:
The disposable filtration device is equipped with sensors that continuously monitor process parameters such as flow rate, pressure, and filtration status. These sensors provide real-time feedback to an external control system, which can detect deviations from normal operation and automatically adjust or alert operators. This feedback mechanism maintains process reliability while preserving the simplicity of disposable device operation.
Data Source
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AI summary
An automated single-use filtering apparatus (10), in particular for large-volume filtering processes, comprises an unfiltered matter inlet (56), one or more filter elements, a filtered matter outlet (58), sensors for sensing certain process parameters, and setting devices for adjusting certain process parameters. The sensors and setting devices are connected to an external monitoring and control system (78) designed to analyze and process sensor data and control the setting devices on the basis of one or more control algorithms.