Automatic Analyzer Calibration Correction for Reagent Water Evaporation
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Solution Overview
Problem
Existing automatic analyzers face challenges in maintaining measurement accuracy due to reagent concentration caused by water evaporation, which affects the calibration curve's blank value and gradient, necessitating frequent recalibration.
Innovation Solution
The automatic analyzer employs a correction function to calculate a correction coefficient based on two calibration measurements, adjusting the calibration curve's gradient and blank value to compensate for reagent concentration, using a photometer to measure absorbance and generate a corrected calibration curve.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If reagent is used for several days, then the reagent may be concentrated due to water evaporation, but the measuring accuracy deteriorates because reagent concentration affects the blank value and gradient of the calibration curve
Solution Approach 1:
The patent applies parameter changes by detecting the blank value of the reagent and using this parameter to calculate a correction coefficient that adjusts the calibration curve. The system changes the calibration parameters (gradient and blank value) based on the detected reagent blank value, allowing accurate measurements even when reagent concentration changes due to evaporation over time
Solution Approach 2:
The patent implements feedback by continuously monitoring the blank value of the reagent and using this information to automatically correct the calibration curve. The system measures the blank value, compares it to expected values, calculates a correction coefficient, and applies this correction to maintain measurement accuracy throughout the reagent's usage period
2Measurement precision
If a new calibration measurement is performed frequently to maintain accuracy, then the measuring precision is improved, but the productivity deteriorates due to time loss from repeated calibration operations
Solution Approach 1:
The system uses feedback by automatically detecting the reagent blank value during normal operation and using this information to correct the calibration curve without requiring full recalibration. This continuous monitoring and automatic correction maintains accuracy while avoiding the productivity loss associated with frequent manual recalibration operations
Solution Approach 2:
The patent applies self-service by enabling the system to automatically detect reagent blank values and perform calibration corrections without user intervention. The automatic calibration correction function operates independently, eliminating the need for operators to perform time-consuming recalibration procedures while maintaining measurement precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method ensures accurate measurement of samples even when reagents are concentrated, improving measurement precision by correcting the calibration curve based on reagent concentration changes.
Implementation Method 1
using a photometer to measure absorbance and generate a corrected calibration curve
Data Source
AI summary
An automatic analyzer disclosed herein includes a first calibration curve generator configured to generate a first calibration curve indicating a relationship between a concentration and an absorbance based on a result of an optical measurement of a reaction solution obtained by adding a reagent to a reference sample including a known concentration of an object to be detected; and a corrected calibration curve generator configured to generate, after the first calibration curve is generated, a corrected calibration curve based on a result of an optical measurement of a mixed reaction solution obtained by mixing the reagent and the reference sample or water, or an optical measurement of the reagent, and data relating to the first calibration curve.