Automatic Perfusion Measurement via Fluorescence Imaging
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Solution Overview
Problem
Current fluorescence imaging methods for perfusion assessment in medical procedures are limited by manual administration and discrete measurements, leading to prolonged surgery times and subjective assessments, which can result in inadequate perfusion evaluation and increased morbidity during emergency procedures.
Innovation Solution
A system for automatic perfusion assessment using a controllable injection pump to administer predefined doses of fluorescence imaging agents, allowing for continuous measurement and analysis of perfusion parameters through image processing, enabling repeated measurements with reduced doses and minimized wash-out periods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Illumination intensity
If a substantial dose of fluorescent agent is administered to ensure a strong visual signal, then the fluorescence emission is sufficient for surgeon visualization, but the wash-out period is prolonged (20-30 minutes) during which background fluorescence hinders new measurements
Solution Approach 1:
The patent replaces subjective visual assessment with automated computer-based image analysis. The system automatically captures fluorescence images, processes them through algorithms, and generates quantitative perfusion maps, eliminating the need for surgeons to visually interpret fluorescence signals and reducing measurement time.
Solution Approach 2:
The system performs self-assessment by automatically analyzing fluorescence images and generating perfusion evaluations without requiring surgeon intervention or interpretation. The automated image processing and quantitative analysis enable the system to independently assess perfusion status.
2Ease of operation
If manual administration and discrete measurements are used, then the system is simple to operate, but surgery time is prolonged due to multiple manual steps and waiting periods
Solution Approach 1:
The system enables continuous fluorescence imaging and real-time perfusion assessment throughout the surgical procedure. Instead of discrete intermittent measurements, the automated system continuously monitors perfusion status, providing ongoing feedback without interrupting the surgical workflow.
Solution Approach 2:
The system performs automated image capture and analysis in real-time during surgery, eliminating the need for pre-planned discrete measurement points. The continuous monitoring approach allows perfusion assessment at any critical moment without pausing the surgical procedure.
3Loss of time
If only a few discrete perfusion measurements are conducted at critical points, then the measurement process is quick, but the assessment is incomplete and may miss important perfusion changes
Solution Approach 1:
The system provides continuous real-time perfusion monitoring throughout the surgical procedure, capturing perfusion dynamics at all stages rather than at discrete predetermined points. This continuous assessment ensures no important perfusion changes are missed while maintaining efficient operation.
Solution Approach 2:
The system provides real-time feedback on perfusion status through automated image analysis and quantitative mapping. This continuous feedback loop allows immediate detection of perfusion changes and enables timely surgical interventions to address compromised tissue.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces surgery time, enhances the accuracy of perfusion assessments, and allows for continuous monitoring of tissue viability, improving surgical outcomes by providing objective and timely perfusion data.
Implementation Method 1
Injection of fluorescence imaging agents, aka fluorescent contrast agents, aka fluorescent agents, such as indocyanine green (ICG), to visualize blood flow and perfusion in anatomical structures
Data Source
AI summary
The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent.