Autonomic Nervous System Modulation for Parasympathetic Bias

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Solution Overview

Problem

Current treatment options for health conditions often focus on symptom relief rather than addressing the underlying causes, leading to a need for new protocols that target the root of the issue rather than just the symptoms.

Innovation Solution

Modulating the autonomic nervous system by increasing the sympathetic/parasympathetic activity ratio through pharmacological and electrical means to treat parasympathetic bias mediated conditions, which involves administering effective amounts of pharmacological agents or applying electrical stimulation to specific areas of the autonomic nervous system.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If current treatment options are used, then symptom relief is achieved, but the underlying cause of the condition is not addressed

Engineering Contradiction:
Improvesymptom reliefVSAvoidcurative effect
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent extracts and targets the underlying cause of conditions by identifying and modulating specific autonomic nervous system imbalances (parasympathetic bias) rather than treating symptoms. This is achieved through electrical stimulation devices that directly influence autonomic nervous system activity to correct the root cause.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent uses electrical stimulation as an intermediary mechanism to modulate autonomic nervous system activity. The stimulation device acts as a mediator between external control and the autonomic nervous system, enabling precise control over sympathetic and parasympathetic balance to treat underlying causes.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If the autonomic nervous system is modulated to increase sympathetic/parasympathetic activity ratio, then the underlying condition is treated, but treatment complexity increases

Engineering Contradiction:
Improvecurative effectVSAvoidtreatment protocol complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent employs a universal electrical stimulation device that can treat multiple different conditions by modulating autonomic nervous system balance. The same basic device platform addresses various conditions including IBS, asthma, allergies, and other parasympathetic bias-mediated conditions, reducing overall treatment complexity despite the sophisticated physiological mechanisms involved.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS10426950B2Methods and devices for treating parasympathetic bias mediated conditions
Publication Date: 2019.10.01 PALO ALTO INVESTORS LP
  • US10426950B2 patent drawing

AI summary

Methods for treating a subject for a parasympathetic bias mediated condition are provided. Aspects of the methods include modulating at least a portion of the subject's autonomic nervous system to increase the sympathetic/parasympathetic activity ratio in a manner effective to treat the subject for the parasympathetic bias mediated condition. In some instances, the subject is known to have parasympathetic bias. Also provided are devices that find use in practicing various embodiments of the methods.