Autonomic Nervous System Modulation for Renal Disease Treatment
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Solution Overview
Problem
Current treatments for renal failure are often invasive and may require blood transfusions, plasma exchange, and dialysis, highlighting a need for new therapeutic modalities to effectively manage renal conditions.
Innovation Solution
Modulating the autonomic nervous system, specifically by adjusting the parasympathetic/sympathetic activity ratio, through pharmacological agents or electrical energy application to treat renal conditions, thereby addressing the underlying hormonal imbalances associated with renal failure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for renal failure are used (blood transfusions, plasma exchange, dialysis), then renal function can be maintained or improved, but the treatment becomes invasive and complex
Solution Approach 1:
The patent replaces mechanical/invasive treatment systems (dialysis machines, catheters, transfusion equipment) with a pharmacological composition that can be administered systemically. The composition targets the underlying hormonal imbalances (sympathetic overactivity, renin-angiotensin-aldosterone system activation) rather than mechanically removing waste or replacing fluids, thereby maintaining renal function through biochemical modulation instead of invasive procedures
Solution Approach 2:
The patent introduces a pharmacological intermediary (the composition containing multiple active ingredients) that mediates between the hormonal imbalances causing renal failure and the desired therapeutic outcome. The composition acts as a mediator to block pathological pathways (sympathetic activation, RAAS overactivity) and restore physiological balance, avoiding the need for direct mechanical intervention
2Productivity
If invasive procedures are used to treat renal failure, then immediate relief of symptoms can be achieved, but the treatment requires repeated aggressive interventions
Solution Approach 1:
The patent applies preliminary action by addressing the root hormonal imbalances and pathological mechanisms (sympathetic overactivity, RAAS activation) before they progress to severe renal failure requiring repeated interventions. By modulating these underlying pathways early, the treatment prevents the need for frequent aggressive procedures and reduces treatment frequency over time
Data Source
AI summary
Methods for treating a renal associated disease condition in a subject are provided. The subject methods are characterized by modulating at least one portion of the subject's autonomic nervous system in a manner effective to treat a renal condition in the subject. Specifically, the methods may include modulating, e.g., increasing, a parasympathetic/sympathetic activity ratio in the subject. Also provided are compositions, kits and systems for practicing the subject methods.