Autophagy Inducer Compositions for Intermittent Fasting
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current intermittent fasting regimens lack solutions that target autophagy to enhance benefits such as longevity and cellular renewal, primarily focusing on weight loss with mediums like MCTs.
Innovation Solution
Administering an autophagy inducer, such as thymol, carvacrol, spermidine, or urolithin, before, during, or after intermittent fasting to induce autophagy, promoting protein synthesis and removal of damaged cellular materials, while optionally combining with MCTs to enhance satiety.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If intermittent fasting is used for weight loss, then weight loss is achieved, but other health benefits such as longevity and cellular renewal are not optimized
Solution Approach 1:
The patent combines intermittent fasting with autophagy inducers (such as spermidine, resveratrol, metformin, or rapamycin) to merge two separate mechanisms - caloric restriction and autophagy induction - into a unified therapeutic approach. This combination aims to achieve both weight loss and enhanced cellular renewal, longevity, and metabolic health benefits that neither intervention alone can fully provide.
2Ease of operation
If only MCTs are used during intermittent fasting, then satiety is promoted, but autophagy induction is insufficient
Solution Approach 1:
The patent creates a composite nutritional intervention by combining medium-chain triglycerides (MCTs) with autophagy-inducing compounds. The MCTs provide satiety and metabolic benefits during fasting, while the autophagy inducers (such as spermidine, resveratrol, metformin, or rapamycin) simultaneously trigger cellular recycling processes. This composite approach addresses both satiety needs and autophagy induction requirements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of autophagy inducers with intermittent fasting regimens improves longevity, cardiometabolic health, cellular renewal, ketosis, weight loss, glycemic control, and satiety, addressing the limitations of existing solutions by targeting autophagy for enhanced benefits.
Implementation Method 1
Fasting has been shown to trigger autophagy, which is a mechanism at the crossroad of intermittent fasting benefits such as longevity. Indeed, autophagy is a cellular recycling process implicated in cellular renewal.
Data Source
AI summary
Compositions contain an autophagy inducer and are administered before, during and/or after an intermittent fasting (IF) diet, preferably a time-restricted feeding (TRF) regimen or an alternate day fasting (ADF) regimen. For example, enhanced intermittent fasting provided by the compositions and methods disclosed herein can include improvement of at least one of longevity, cardiometabolic health, body composition (e.g., fat mass reduction), cellular ageing (e.g., reduction in inflammation markers), cellular renewal, ketosis, weight loss, glycemic control, blood pressure, satiety, or treatment of gastroesophageal reflux disease (GERD). Another aspect is a method of treating or preventing an inflammatory condition, such as rheumatoid arthritis and/or osteoarthritis, by administering an autophagy inducer before, during and/or after an intermittent fasting (IF) diet. An example of an autophagy inducer suitable for the compositions and methods is thymol, optionally in combination with medium chain triglycerides (MCTs).