Autosampler Agitation System for Uniform Sample Mixing

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Solution Overview

Problem

In laboratory settings, analyzing large numbers of biochemical or chemical samples simultaneously often results in concentration gradients and uneven sample preparation, leading to inaccurate test results, as existing methods for sample agitation are time-consuming and inefficient.

Innovation Solution

An automated sample agitation system that includes a sample probe with an actuator capable of rotational oscillation within a sample vessel, allowing for efficient stirring and mixing of samples, including those with immiscible liquids or solids, to achieve uniformity and consistency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If manual sample agitation methods are used, then sample mixing can be achieved, but sample preparation time is excessive and efficiency is low

Engineering Contradiction:
Improvesample preparation efficiencyVSAvoidsample preparation time
Core Design Contradiction:
ProductivityVSLoss of time

Solution Approach 1:

The sample probe performs self-agitation by utilizing its own movement and positioning capabilities to stir and mix samples within vessels, eliminating the need for separate agitation devices and reducing overall system complexity while improving efficiency

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The sample probe is designed to perform multiple functions including sampling, agitation, and mixing operations across different vessel types and sample configurations, replacing multiple specialized tools with a single versatile device

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Measurement precision

If existing agitation methods are used, then samples can be mixed, but concentration gradients and uneven preparation occur leading to inaccurate results

Engineering Contradiction:
Improvetest result accuracyVSAvoidsample uniformity
Core Design Contradiction:
Measurement precisionVSStability of the object's composition

Solution Approach 1:

The sample probe employs dynamic movement patterns including rotational oscillation and varied positioning strategies to create thorough mixing action that eliminates concentration gradients and ensures homogeneous sample preparation for accurate testing

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The sample probe utilizes vibrational motion and oscillatory movements to enhance mixing effectiveness, breaking up stagnant zones and ensuring complete dispersion of samples for uniform composition

Inventive Principle:
Principle #18Mechanical vibration

3Productivity

If automated sampling is implemented, then testing efficiency is enhanced, but sample agitation remains time-consuming and inefficient

Engineering Contradiction:
Improvesample testing efficiencyVSAvoidagitation system complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The agitation functionality is merged with the existing sample probe structure, integrating mixing capabilities into the sampling mechanism itself rather than adding separate agitation equipment, thus maintaining automation benefits while avoiding increased system complexity

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system significantly reduces sample preparation time and enhances the accuracy of test results by ensuring uniform sample mixing, facilitating rapid and consistent agitation of samples within automated sampling devices.

Implementation Method 1

an actuator coupled to the sample probe that is configured to stir the sample positioned within the sample vessel in one or more rotational directions

Methodology Applied
Scientific EffectStirring: Stirring

Implementation Method 2

actuating the sample probe to rotationally oscillate within the sample vessel

Methodology Applied
Scientific EffectRotational oscillation: Vibration

Data Source

PatentUS11397142B1Autosampler with sample agitation system
Publication Date: 2022.07.26 ELEMENTAL SCI
  • US11397142B1 patent drawing
  • US11397142B1 patent drawing
  • US11397142B1 patent drawing

AI summary

A sample agitation system for an automated sampling device is described. In an example implementation, the sample agitation system includes a sample probe configured to contact a sample positioned within a sample vessel. Further, the sample agitation system includes an actuator coupled to the sample probe that is configured to stir the sample positioned within the sample vessel in one or more rotational directions. The directions may include, but are not limited to, clockwise motion, anti-clockwise motion, or the like. In some implementations, a sample probe support arm can be coupled to the sample probe and/or the actuator. The actuator can move the sample probe support arm in a translational, a rotational, and/or a vertical direction to rotate the sample probe and stir the sample.