Autosampler Parallel Operations for Electrophoretic Light Scattering
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Solution Overview
Problem
Existing light scattering instruments face inefficiencies in automation workflows, particularly in environments requiring large numbers of sample measurements, due to time-consuming steps in sample collection, injection, washing, and measurement operations.
Innovation Solution
A computer-implemented method and apparatus for an electrophoretic light scattering analysis system that dynamically displays results and contemporaneously performs sample collection, injection, and storage unit washing operations, using a special-purpose computer system to streamline these processes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional sequential operations are used for sample collection, injection, washing, and measurement, then each operation can be performed with sufficient precision, but the total time required for completing a large number of sample measurements increases significantly
Solution Approach 1:
The system performs sample collection, injection, washing, and measurement operations in a continuous parallel manner rather than sequentially. Multiple operations occur simultaneously across different samples, eliminating idle time between operations and maintaining continuous productive action throughout the measurement process.
Solution Approach 2:
The autosampler pre-positions samples and prepares injection mechanisms in advance before measurements are required. Sample trays are pre-loaded, and the system anticipates measurement needs to perform preparatory actions ahead of time, reducing waiting time during actual measurement operations.
2Measurement precision
If manual parameter entry is performed for each sample, then parameter accuracy can be ensured, but the time required to populate the instrument with measurement information increases significantly
Solution Approach 1:
The system uses templates to store parameter configurations that can be copied and applied to multiple samples. Instead of manually entering parameters for each sample, users create a master template with desired parameters and automatically replicate it across all samples or selected groups, ensuring consistency and accuracy while dramatically reducing entry time.
Solution Approach 2:
The parameter entry system serves multiple functions: it allows individual sample configuration, batch template creation, automatic parameter inheritance, and dynamic modification during experiments. This multi-functional approach replaces multiple separate manual operations with a unified parameter management system.
3Reliability
If comprehensive washing operations are performed between samples, then cross-contamination is prevented, but the total operation time increases
Solution Approach 1:
The system merges washing operations with sample injection and measurement operations. Washing occurs simultaneously with other operations rather than as a separate sequential step. The wash solvent delivery is integrated with the injection mechanism, allowing cleaning to occur during transitions between samples without adding dedicated washing time.
Data Source
AI summary
A method for sample analysis comprises loading a plurality of samples into a plurality of sample storage vessels of a liquid chromatography instrument; receiving a plurality of parameters corresponding to the plurality of samples, the sample storage vessels holding samples of the plurality of samples having different parameters; dynamically displaying results from a measurement operation by an electrophoretic light scattering measurement instrument of the samples having the different parameters; and contemporaneously performing a combination of sample collection operations, sample injection operations, and sample storage unit washing operations.