Autosampler Syringe Switching Logic for Malfunction Recovery

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Solution Overview

Problem

Scientific instruments face downtime and wasted resources due to undetected syringe malfunctions, which conventional approaches fail to address effectively, leading to decreased laboratory throughput and data quality.

Innovation Solution

A scientific instrument support system with evaluation logic to identify syringe issues like bent needles or plungers, syringe logic to switch to a backup syringe, and reporting logic to notify users, implemented through a computing device, enabling automatic detection and recovery from syringe malfunctions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional approaches are used without automatic detection, then device complexity is reduced, but reliability deteriorates due to undetected syringe malfunctions

Engineering Contradiction:
Improvesyringe malfunction detectionVSAvoidevaluation logic implementation
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The syringe system performs self-diagnosis through evaluation logic that automatically detects malfunctions such as bent needles, blocked needles, stuck plungers, and injection anomalies. The system monitors its own operational status and triggers automatic syringe replacement without external intervention, enabling the instrument to service itself and maintain high reliability.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The system implements continuous feedback through evaluation logic that monitors syringe performance in real-time. When anomalies are detected in chromatographic datasets or through image analysis, the system provides feedback to trigger syringe replacement. This closed-loop feedback mechanism ensures reliable detection and response to syringe malfunctions.

Inventive Principle:
Principle #23Feedback

2Productivity

If automatic syringe switching is implemented, then productivity is improved by reducing downtime, but device complexity increases due to multiple syringe seats and switching logic

Engineering Contradiction:
Improvelaboratory throughputVSAvoidsyringe switching mechanism
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The autosampler is divided into multiple independent syringe seats, allowing one syringe to be used while another is prepared or replaced. This segmentation enables continuous operation without downtime, as the system can switch between syringes seamlessly. The evaluation logic independently monitors each syringe and triggers switching only when necessary, maintaining simplicity while improving productivity.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The system performs preliminary evaluation of syringe status before malfunctions occur through continuous monitoring of injection parameters and image analysis. When a syringe shows signs of malfunction, the system prepares for switching in advance by identifying alternative syringes, ensuring minimal disruption to productivity and smooth transitions.

Inventive Principle:
Principle #10Preliminary action

3Reliability

If multiple syringe seats are added to enable switching, then reliability is improved through backup syringes, but device complexity increases due to additional components

Engineering Contradiction:
Improvecontinuous operation capabilityVSAvoidmultiple syringe seats
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

Multiple syringe seats are designed with universal compatibility to accommodate different syringe types and sizes. The evaluation logic and switching mechanism work uniformly across all syringe seats, allowing the system to maintain high reliability through backup syringes without proportionally increasing complexity. Each syringe seat serves multiple functions: active sampling, standby replacement, and initialization.

Inventive Principle:
Principle #6Universality (Multi-functionality)

4Measurement precision

If image analysis is used to detect bent needles or plungers, then measurement precision is improved, but device complexity increases due to additional sensors and processing

Engineering Contradiction:
Improvesyringe defect detection accuracyVSAvoidimage data processing system
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system replaces complex mechanical inspection methods with optical image analysis and chromatographic data evaluation. Image capture devices and sensors detect bent needles or plungers through optical fields, and evaluation logic processes the image data to identify anomalies. This substitution achieves high measurement precision while reducing mechanical complexity compared to physical inspection mechanisms.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Data Source

PatentEP4270001A1Intelligent syringe changing capability with multiple syringe seats on autosampler
Publication Date: 2023.11.01 THERMO FINNIGAN LLC
  • EP4270001A1 patent drawingFigure 1~2
  • EP4270001A1 patent drawingFigure 3~4
  • EP4270001A1 patent drawingFigure 5

AI summary

Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes evaluation logic to identify a first syringe has a bent needle, a bent plunger, a blocked needle, or a stuck plunger; syringe logic to switch from the first syringe to a second syringe; and reporting logic to notify a user of a syringe problem.