Avenanthramide Skin Penetration Using Diol Enhancers
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Solution Overview
Problem
Avenanthramides, due to their hydrophilic nature, exhibit poor permeation through the stratum corneum, making it challenging to achieve therapeutic concentrations and topical bioavailability for skin applications.
Innovation Solution
A composition comprising avenanthramides combined with penetration enhancers such as diols, polyols, and alcohols, specifically 1,2-hexanediol and 1,2-octanediol, to enhance skin penetration and bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If avenanthramides are applied topically, then antioxidant and anti-inflammatory benefits are provided, but poor skin penetration limits therapeutic concentrations and bioavailability
Solution Approach 1:
The patent employs penetration enhancers as intermediary substances to facilitate the transport of avenanthramides through the stratum corneum. These enhancers act as mediators that temporarily modify the skin barrier properties or form delivery vehicles (microemulsions, liposomes) to enable deeper penetration of the hydrophilic avenanthramide molecules, thereby achieving therapeutic concentrations in the skin without compromising their antioxidant and anti-inflammatory benefits
2Reliability
If penetration enhancers are added to improve skin permeation, then bioavailability increases, but formulation complexity increases
Solution Approach 1:
The patent modifies the physicochemical parameters of the avenanthramide formulation by incorporating penetration enhancers that alter solubility, partitioning behavior, and molecular aggregation states. This includes adjusting pH, ionic strength, and using solubilizing agents to transform the delivery system from a simple aqueous solution to a more complex but optimized formulation that achieves superior skin penetration and bioavailability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Significantly improves the penetration and permeation of avenanthramides into the skin, increasing their bioavailability and effectiveness for skin and scalp care, and the treatment of dermatological conditions.
Implementation Method 1
Avenanthramides, due to their hydrophilic nature, exhibit poor permeation through the stratum corneum. A composition comprising avenanthramides combined with penetration enhancers such as diols, polyols, and alcohols, specifically 1,2-hexanediol and 1,2-octanediol, to enhance skin penetration and bioavailability.
Data Source
AI summary
The present invention relates generally to: a composition comprising or consisting of a specific avenanthramide and at least one penetration enhancer with an improved skin penetration; a method for preparing said composition; the use of such compositions as cosmetics or pharmaceuticals; and cosmetics or pharmaceuticals comprising said composition.