Avenanthramide Stabilization Using Chelating Agents
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Solution Overview
Problem
Avenanthramides, due to their chemical structure, are unstable compounds that degrade easily, leading to reduced efficacy in cosmetic and pharmaceutical applications, and existing stabilizers like vitamin C cause discoloration, making it challenging to maintain their antioxidant activity and bioavailability.
Innovation Solution
A composition comprising avenanthramides or their analogues stabilized with chelating agents, organic acids, or antioxidants, such as EDTA, ascorbic acid, and phytic acid, which enhance stability without causing discoloration, allowing for prolonged shelf life and maintained biological activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If avenanthramides are used in cosmetic and pharmaceutical preparations, then antioxidant activity and biological efficacy are improved, but stability during storage deteriorates due to easy degradation
Solution Approach 1:
The patent employs stabilizers as intermediary substances that mediate between the avenanthramides and degrading environmental factors. These stabilizers form protective complexes with avenanthramides, preventing direct interaction with oxygen, light, and metal ions that cause degradation, thereby maintaining antioxidant activity while improving storage stability.
Solution Approach 2:
The patent creates composite formulations by combining avenanthramides with stabilizing agents in specific ratios. This composite approach allows the synergistic interaction between components, where the stabilizer protects the avenanthramide structure while maintaining its biological activity, resolving the contradiction between efficacy and stability.
2Stability of the object's composition
If existing stabilizers like vitamin C are used to improve stability, then degradation is reduced, but discoloration occurs making the product less acceptable
Solution Approach 1:
The patent employs alternative stabilizers that serve as sacrificial protective agents. These stabilizers preferentially react with degrading factors (oxygen, radicals) to protect avenanthramides, and their eventual degradation products do not cause discoloration, unlike vitamin C which turns brown upon oxidation.
Solution Approach 2:
The patent changes the chemical parameters of the stabilizing system by selecting stabilizers with different oxidation pathways and products. The chosen stabilizers undergo degradation that does not produce colored compounds, fundamentally altering the discoloration parameter while maintaining protective function.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of these stabilizers significantly inhibits the degradation of avenanthramides, particularly avenanthramide C, maintaining their biological activity and preventing discoloration, thus ensuring the composition's effectiveness and stability during storage and use.
Implementation Method 1
at least one stabilizer selected from the group consisting of chelating agents, organic acids, antioxidants and mixtures thereof
Implementation Method 2
The antioxidant activity of phenolic compounds is related to the number and position of hydroxyl groups in the molecule... the ability of phenolic compounds to scavenge free radicals, donate hydrogen atoms or electrons
Data Source
AI summary
The present invention relates generally to: a composition comprising or consisting at least one avenanthramide or an analogue thereof or an oat extract comprising an avenanthramide or an analogue thereof with an improved stability; its cosmetic or medical use; the use of such composition for the preparation of foods, food supplements, cosmetic, pharmaceutical or veterinary preparations; and foods, food supplements, cosmetic, pharmaceutical or veterinary preparations comprising such a composition. Finally, the present invention relates to specific stabilizers for the stabilisation of avenanthramide(s).