Avermectin Pour-On Formulation Reducing Meat Withdrawal Time
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Solution Overview
Problem
Conventional formulations for treating ectoparasites and endoparasites in meat-producing animals require prolonged withdrawal periods for edible tissues, which is a limitation in the meat industry.
Innovation Solution
A topical formulation comprising 0.001% to 15% w/v avermectin, at least 60% w/v isopropyl alcohol, and up to 30% w/v propylene glycol dicaprylate/caprate or caprylic acid/capric triglyceride, without polymeric materials, allowing for steady absorption through the skin and reducing meat withdrawal time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional formulations of avermectins are used for treating parasites in meat-producing animals, then effective parasite control is achieved, but the meat withdrawal period is prolonged (15 days or more)
Solution Approach 1:
The patent changes the formulation parameters by using a polymeric material-free composition with specific solvent ratios (isopropyl alcohol and oils) and avermectin concentrations (0.001-15% w/v). This parameter modification enables the formulation to achieve both effective parasite control and reduced meat withdrawal time (less than 15 days, and in some cases less than 10 days), resolving the contradiction between efficacy and withdrawal period duration
Solution Approach 2:
The invention uses a composite formulation system combining avermectins with specific oils (propylene glycol dicaprylate/caprate, carprylic acid/capric triglyceride) and solvents (isopropyl alcohol) without polymeric materials. This composite approach creates a synergistic effect that improves both the antiparasitic efficacy and the absorption kinetics, leading to reduced residue levels in meat tissues and shorter withdrawal periods while maintaining reliable parasite control
2Reliability
If oral dosage forms of avermectin are used, then parasite treatment is effective, but blood level peaks and troughs occur
Solution Approach 1:
The patent replaces the oral administration route with topical application. This substitution changes the absorption mechanism from gastrointestinal to transdermal, eliminating the first-pass metabolism and the resulting blood level peaks and troughs. The topical formulation provides more stable and sustained blood concentrations while maintaining effective parasite treatment
Solution Approach 2:
The formulation uses oils and solvents as intermediaries to facilitate controlled transdermal absorption of avermectin. These intermediary substances enable steady release and absorption kinetics, preventing the abrupt blood level fluctuations seen with oral dosing while ensuring adequate therapeutic levels are achieved for effective parasite control
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation effectively treats parasites while significantly reducing the meat withdrawal period to less than 15 days, even less than 10 days, by avoiding blood level peaks and ensuring avermectin residues are within safe limits in edible tissues.
Implementation Method 1
The composition is advantageous as it allows the avermectin to be absorbed steadily through the skin over a period of time
Data Source
AI summary
A topical anti-parasitic composition comprising: (i) from about 0.001% w/v to about 15% w/v of at least one avermectine, based on the total weight of the composition; (ii) at least about 60% w/v of a solvent, based on the total weight of the composition; and (iii) at least one oil in an amount of up to about 30 % w/vl based on the total weight of the composition, where in the composition is free of polymeric material.