Avian Feather Extract for Resolving Antibiotic Resistance
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Solution Overview
Problem
Current treatments for microbial skin infections, including bacterial, fungal, and viral infections, often result in pain and antibiotic resistance, necessitating a novel pharmaceutical composition for effective treatment and prevention.
Innovation Solution
A composition comprising nicotinamide, 2,4-ditert butyl phenol, palmitic acid, oleic acid, and squalene, combined with a pharmaceutically acceptable carrier, derived from an avian extract, specifically from the feathers of birds like the sulphur-crested cockatoo, for topical or parenteral application to treat a range of microbial skin infections.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antibiotics are used to treat bacterial skin infections, then the infection is treated, but antibiotic resistance develops
Solution Approach 1:
The patent extracts and utilizes naturally occurring antimicrobial substances from avian feathers, specifically identifying and isolating compounds like prenenol and other terpenes that possess inherent antimicrobial properties. This approach replaces synthetic antibiotics with naturally derived alternatives that treat infections without contributing to resistance development.
Solution Approach 2:
The patent employs avian feather extract as an intermediary substance that mediates between the need for effective infection treatment and the avoidance of harmful side effects. The extract contains multiple bioactive compounds that work synergistically to combat microbial infections while maintaining safety and avoiding resistance issues associated with conventional antibiotics.
2Reliability
If physical treatments such as debridement or burning are used, then infections are treated, but pain is caused to the patient
Solution Approach 1:
The patent replaces mechanical and thermal physical treatments (debridement, burning) with a chemical/biological solution based on avian feather extract. The extract's antimicrobial compounds chemically inhibit and kill pathogens without requiring physical destruction of tissue, thereby eliminating the pain associated with traditional physical treatments while maintaining therapeutic effectiveness.
3Reliability
If conventional treatments are used, then infections are treated, but side effects occur
Solution Approach 1:
The patent changes the fundamental parameter of treatment composition from synthetic chemicals and harsh physical agents to natural avian feather extract containing bioactive compounds. This parameter change fundamentally alters the safety profile by using substances that are biocompatible and have minimal side effects while retaining potent antimicrobial, antifungal, and antiviral activities.
Data Source
AI summary
A method for treating or preventing microbial skin infections comprising the step of: administering to a subject in need thereof a composition comprising avian extract EP-2 in a therapeutically effective concentration together with a pharmaceutically acceptable carrier and/or diluent.,