Avocado Perseose Protects Epidermal Stem Cells

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Solution Overview

Problem

The skin of infants and young children is immature, leading to impaired barrier function and increased susceptibility to environmental stressors, which can result in skin aging, fragility, and increased risk of skin cancers due to the immaturity of epidermal stem cells and the stratum corneum.

Innovation Solution

The use of C7 sugars, such as avocado perseose and their derivatives, which protect epidermal stem cells by maintaining the expression of stem cell markers, thereby preserving the skin's natural barrier function and promoting skin homeostasis and regeneration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If the skin is left to mature naturally without intervention, then the barrier function develops over time, but the skin remains vulnerable to environmental stressors during the immature period, leading to potential damage and premature aging

Engineering Contradiction:

Improvebarrier functionVSAvoidenvironmental stressors

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies preliminary action by using C7 sugars to protect epidermal stem cells before the skin's barrier function is fully matured. The composition is applied to infant skin to preemptively shield stem cells from environmental aggressors during the vulnerable immature period, preventing damage before it occurs rather than treating it after maturation

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The C7 sugars act as an intermediary substance between environmental stressors and epidermal stem cells. The composition containing C7 sugars mediates the interaction by forming a protective interface that filters harmful UV rays and other environmental factors, allowing the skin to mature without direct exposure to damaging agents

Inventive Principle:

Principle #24Intermediary (Mediator)

2Adaptability or versatility

If epidermal stem cells are exposed to environmental aggressors during skin maturation, then the skin adapts to the environment, but the stem cells suffer damage leading to reduced regenerative capacity and increased risk of skin cancers

Engineering Contradiction:

Improveenvironmental adaptationVSAvoidstem cell regenerative capacity

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent converts the harmful effect of environmental aggressors into a beneficial outcome by using C7 sugars to selectively filter damage. The composition allows controlled exposure that stimulates necessary adaptation while blocking harmful elements, transforming potential harm into beneficial maturation without compromising stem cell integrity

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The invention applies local quality by providing differential protection to different skin components. The C7 sugars specifically protect epidermal stem cells while allowing other skin structures to adapt to environmental conditions, creating localized protection where it is most critical rather than uniform protection throughout

Inventive Principle:

Principle #3Local quality

3Stability of the object's composition

If the stratum corneum is thin and immature in infants, then the skin is more flexible and adaptable, but the barrier function is compromised leading to increased water loss and susceptibility to irritants

Engineering Contradiction:

Improvestratum corneum structureVSAvoidbarrier function

Core Design Contradiction:

Stability of the object's compositionVSReliability

Solution Approach 1:

The patent applies beforehand cushioning by using C7 sugars to strengthen the immature stratum corneum before it is fully developed. The composition provides a protective cushioning effect that compensates for the natural weakness of thin infant skin, reducing water loss and protecting against irritants during the maturation process

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

Data Source

PatentEP2953611B1Use of a composition comprising avocado perseose in the protection of epidermal stem cells

Publication Date: 2021.08.18 LAB EXPANSCIENCE SA

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AI summary

The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.