Azelaic Acid Deep Eutectic Composition for Solubility and Stability
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Solution Overview
Problem
Azelaic acid exhibits poor solubility in water and oil, high melting point, and is prone to precipitation, making it difficult to formulate stable and effective large-area cosmetic and drug products.
Innovation Solution
A self-recognition DES system is formed by mixing azelaic acid with betaine and panthenol, enhancing solubility and stability through supramolecular interactions, allowing for a liquid state and direct dilution without phase separation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If azelaic acid is added in high amounts to improve efficacy, then treatment effectiveness increases, but precipitation occurs resulting in system roughness and instability
Solution Approach 1:
The patent uses betaine as an intermediary substance that forms a supramolecular complex with azelaic acid through hydrogen bonding. This mediator prevents azelaic acid precipitation by creating a stable soluble complex, allowing high concentrations of azelaic acid to be maintained in the cosmetic formulation without causing system roughness or instability.
Solution Approach 2:
The patent creates a composite supramolecular system consisting of azelaic acid and betaine molecules self-assembled through hydrogen bonds. This composite material exhibits enhanced solubility and stability compared to pure azelaic acid, enabling high concentrations to be incorporated into water-based cosmetic formulations while maintaining system homogeneity and preventing precipitation.
2Quantity of substance
If encapsulation treatment is used to enhance solubility, then water solubility improves, but the inclusion system becomes sticky and causes poor skin feeling
Solution Approach 1:
The patent changes the molecular state of azelaic acid from crystalline solid to soluble supramolecular complex by altering the chemical environment through betaine addition. This parameter change in molecular organization and solvation state enhances water solubility while maintaining a non-sticky, cosmetically acceptable formulation that provides good skin feeling.
3Quantity of substance
If solubilization with stabilizers is used to form colloids, then solubility improves, but penetration of azelaic acid into skin is hindered
Solution Approach 1:
The patent creates a supramolecular complex that replicates the molecular structure and properties of pure azelaic acid while improving solubility. The betaine-azelaic acid complex maintains the pharmacologically active structure of azelaic acid, enabling it to penetrate skin effectively while being soluble in water-based formulations, unlike bulky colloid stabilizers that would block penetration.
4Quantity of substance
If ultrafine grinding is used to improve solubility, then particle size decreases, but additional cost increases and significant solubilization is not achieved
Solution Approach 1:
The patent changes the chemical environment and molecular interactions by introducing betaine, which forms hydrogen-bonded supramolecular complexes with azelaic acid. This chemical parameter change dramatically enhances solubility without requiring mechanical size reduction, avoiding the high costs of ultrafine grinding equipment and processing while achieving superior solubilization效果.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The azelaic acid/betaine/panthenol DES system achieves high solubility and stability, enabling broad application in cosmetics and drugs with improved moisturizing performance and ease of formulation.
Implementation Method 1
azelaic acid self-recognition
Implementation Method 2
supramolecular hydrogen bonds between molecules
Data Source
Figure 1~2
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Figure 5~7
AI summary
Disclosed in the present invention are an azelaic acid/betaine/panthenol self-recognition DES system and a preparation method, belonging to the technical field of supermolecules. The preparation method for the azelaic acid/betaine/panthenol self-recognition DES system of the present invention comprises the following steps: mixing azelaic acid, betaine, and panthenol according to a molar ratio of 1:0.4-6:0.7-10, and stirring and heating to obtain an azelaic acid/betaine/panthenol self-recognition DES system. The azelaic acid/betaine/panthenol self-recognition DES system prepared according to the present invention is readily soluble in water, and can be directly diluted by adding water until the mass concentration of azelaic acid is 0.8%-35%, without phase separation and solid precipitation, thereby effectively improving the water solubility and stability of azelaic acid, with the degree of improvement far exceeding that of the prior art.