Azole Fungicide Composition With Additives to Reduce Phytotoxicity

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Solution Overview

Problem

Azole fungicides face issues of phytotoxicity and formulation challenges when used in combination with other pesticides, and copper-based fungicides are limited by phytotoxicity and toxicity, necessitating a composition that enhances their efficacy and safety.

Innovation Solution

A combination of azole fungicides with additives such as thiourea-based compounds, sodium thiosulfate, or alkyl amines is used to reduce phytotoxicity and improve plant health, formulated as a composition that includes steps like preparing an aqueous mixture with these additives.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If azole fungicide is applied to control fungal pathogens, then fungicidal efficacy is improved, but phytotoxicity to susceptible crops increases

Engineering Contradiction:
Improvefungicidal efficacyVSAvoidphytotoxicity
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces copper-based fungicide as an intermediary substance that works synergistically with azole fungicide. The copper component (e.g., copper hydroxide, copper oxychloride) provides alternative mode of action against fungal pathogens while the azole component maintains its fungicidal activity. This combination allows reduced application rates of azole fungicide, thereby reducing phytotoxicity while maintaining or improving overall fungicidal efficacy.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates a composite fungicidal composition combining azole fungicide with copper-based fungicide components. This composite formulation leverages the complementary properties of both substances: the systemic action of azole fungicides and the contact action of copper-based fungicides. The composite material achieves enhanced broad-spectrum activity while allowing lower doses of the more phytotoxic azole component.

Inventive Principle:
Principle #40Composite materials

2Reliability

If copper-based fungicide is used to control pathogens, then broad-spectrum efficacy is improved, but toxicity to user and phytotoxicity to plant increase

Engineering Contradiction:
Improvepathogen control efficacyVSAvoidtoxicity and phytotoxicity
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent merges copper-based fungicide with azole fungicide in a single composition. This combination allows the copper component to provide broad-spectrum contact protection while the azole component provides systemic protection. The synergistic interaction between the two substances enables reduced application rates of copper-based fungicide, thereby reducing user toxicity and phytotoxicity while maintaining broad-spectrum efficacy.

Inventive Principle:
Principle #5Merging (Combining)

3Adaptability or versatility

If azole fungicide is formulated in presence of other pesticides, then pest control versatility is improved, but formulation complexity increases

Engineering Contradiction:
Improvepest control versatilityVSAvoidformulation complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent creates a universal composition that combines azole fungicide with copper-based fungicide, providing multi-functional protection against a broad spectrum of fungal pathogens. This single formulation can replace multiple separate pesticide applications, simplifying the overall pest management program while maintaining versatility. The composition is designed to be stable and compatible, avoiding complex formulation challenges.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination significantly reduces phytotoxicity and allows for increased application rates and frequency of azole fungicides without adverse effects on plants, enhancing pest control and fungal disease management.

Implementation Method 1

A combination comprising (1) an amount of azole fungicide and (2) an amount of additive (I) selected from the group consisting of thiourea-based compounds, sodium thiosulfate, alkyl amine, thioamide-based compounds and any combination thereof

Methodology Applied
Scientific EffectChemical interaction: Chemical Bonding

Data Source

PatentUS20250351828A1Azole fungicide composition
Publication Date: 2025.11.20 ADAMA MAKHTESHIM LTD
  • US20250351828A1 patent drawing
  • US20250351828A1 patent drawing
  • US20250351828A1 patent drawing

AI summary

The present invention provides a combination comprising (1) an amount of azole fungicide and (2) an amount of additive (I) selected from the group consisting of selected from group consisting of thiourea-based compounds, sodium thiosulfate, alkyl amine, thioamide-based compounds and any combination thereof, which may be in the form of a tank mixture or composition. The present invention also provides methods of using of the combinations and compositions disclosed herein and processes of preparing the compositions disclosed herein.