Azole Amide Composition for Broad-Spectrum Pest Control
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Solution Overview
Problem
Existing pesticides are inadequate in effectively controlling animal pests such as insects and acarines, particularly those associated with agriculture, horticulture, forestry, and man-made structures, and there is a need for new compounds with improved efficacy and versatility.
Innovation Solution
Development of novel pesticidally active azole amide compounds, including specific structural variations and agrochemically acceptable salts, which can be applied to control pests by reducing their numbers, eliminating them, or preventing further damage to plants and plant-derived products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing pesticides are used, then some pest control is achieved, but efficacy is inadequate and versatility is limited
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of pesticide compounds through systematic variation of substituents at different positions (R1-R6, A1-A6) on the core heteroaryl-azole-amide framework. This structural parameter optimization enables enhanced binding affinity to pest targets while maintaining solubility and stability properties, thereby improving both efficacy and broad-spectrum activity against insects, acarines, nematodes, and molluscs
Solution Approach 2:
The invention creates composite molecular structures by combining heteroaryl groups with azole and amide functional moieties in a unified molecular framework. This composite approach integrates multiple pharmacophoric elements that work synergistically to achieve enhanced pest control efficacy and expanded spectrum of activity across different pest types and life stages
2Adaptability or versatility
If new azole amide compounds are developed, then broad-spectrum pest control is achieved, but structural complexity increases
Solution Approach 1:
The patent applies segmentation by dividing the complex pesticide molecule into distinct functional modules: a heteroaryl core unit, an azole intermediate unit, and an amide terminal unit with variable substituents. This modular segmentation allows systematic optimization of each module's contribution to pest control activity while managing overall molecular complexity through standardized connection patterns
Solution Approach 2:
The invention implements local quality by introducing specific substituent groups at targeted positions (R1-R6) on the molecular framework to confer localized functions such as enhanced binding affinity, improved metabolic stability, or increased solubility. Each substituent is strategically placed to optimize its specific contribution without unnecessarily complicating the entire molecular structure
Data Source
AI summary
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.