Azoxystrobin Propiconazole Microemulsion Stability
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Solution Overview
Problem
Microemulsions of azoxystrobin, a fungicide with limited water solubility, tend to crystallize and lose stability over time, leading to reduced efficacy and storage issues in formulations without propiconazole.
Innovation Solution
A microemulsifiable concentrate comprising azoxystrobin, propiconazole, and an emulsifier system, which forms a stable oil-in-water microemulsion upon dilution with water, enhancing physical stability and biological efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If microemulsions of azoxystrobin are prepared without propiconazole, then the formulation is simpler, but the physical stability deteriorates due to crystallization over time
Solution Approach 1:
The patent combines azoxystrobin with propiconazole in a microemulsifiable concentrate formulation. This merging of two different active ingredients resolves the technical contradiction by using propiconazole to prevent crystallization of azoxystrobin, thereby improving physical stability while maintaining reasonable formulation complexity through synergistic interaction between the two compounds
2Quantity of substance
If azoxystrobin is used alone in microemulsion form, then the formulation has fewer components, but biological efficacy is reduced due to loss of stability
Solution Approach 1:
The patent merges azoxystrobin with propiconazole in a microemulsion formulation where propiconazole acts as a stabilizer that prevents crystallization of azoxystrobin. This combination maintains higher biological efficacy over time compared to azoxystrobin alone, as the stabilized formulation preserves the active ingredient's effectiveness throughout its shelf life and during application
3Quantity of substance
If aromatic organic solvents are used to solubilize azoxystrobin, then solubility is improved, but ecological properties and toxicity worsen
Solution Approach 1:
The patent changes the formulation parameters by using a microemulsifiable concentrate system with propiconazole and surfactants instead of aromatic organic solvents. This parameter change achieves adequate solubility and dispersibility of azoxystrobin while significantly improving ecological properties and reducing toxicity, as microemulsions use water as the continuous phase and avoid harmful aromatic solvents
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation exhibits prolonged physical stability and improved biological efficacy when diluted, maintaining stability and effectiveness in controlling fungal diseases.
Implementation Method 1
A microemulsifiable concentrate comprising azoxystrobin, propiconazole, and an emulsifier system, which forms a stable oil-in-water microemulsion upon dilution with water
Implementation Method 2
Microemulsions are a subclass of emulsions and are typically clear solutions. In general, microemulsions are characterised by emulsion droplets having average particle sizes between 0.01 and 0.1 micron
Implementation Method 3
Microemulsions of azoxystrobin, a fungicide with limited water solubility, tend to crystallize and lose stability over time, leading to reduced efficacy and storage issues in formulations without propiconazole
Data Source
AI summary
The present invention provides microemulsifiable concentrates and microemulsions comprising azoxystrobin and propiconazole.