Bacillomycin D Side Chain Modification for Plant Disease Control
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Solution Overview
Problem
Current plant disease control agents lack effectiveness and safety, necessitating the development of novel compounds with enhanced antimicrobial activity.
Innovation Solution
The discovery and utilization of novel Bacillomycin D compounds with a side chain of 17 carbon atoms, produced by Bacillus sp., which exhibit superior antimicrobial activity when combined with surfactin, forming a plant disease control agent.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional plant disease control agents are used, then they can control plant diseases, but their effectiveness and safety are insufficient
Solution Approach 1:
The patent changes the chemical structure parameters of Bacillomycin D by modifying the side chain length from conventional C14-C16 to C17, creating novel compounds (Compounds 1 and 2) with superior antimicrobial activity and safety profile for plant disease control
Solution Approach 2:
The patent combines novel Bacillomycin D compounds with surfactin to create a composite plant disease control agent, where the synergistic effect of the two compounds enhances both effectiveness and safety compared to using conventional agents alone
2Reliability
If conventional iturin class compounds are used, then they provide basic antimicrobial activity, but their activity is insufficient compared to novel compounds
Solution Approach 1:
The patent systematically varies the side chain carbon atom number of Bacillomycin D (C14, C15, C16, C17) to optimize antimicrobial activity, finding that C17 side chain compounds exhibit superior activity while maintaining reasonable structural complexity
Solution Approach 2:
The patent focuses on modifying a specific local feature of the molecule (the side chain length of β-amino acid) while keeping the core cyclic peptide structure intact, thereby enhancing activity without excessive complexity increase
Data Source
AI summary
The present invention relates to a plant disease control agent containing a compound represented by the following formula (1) or salt thereof as an active ingredient (in the formula, R1 and R2 represents a hydrogen atom or methyl group but excepting cases where R1 and R2 are the same), a plant disease controlling method applying the plant disease control agent on plants suffering from diseases, and a novel compound represented by formula (1) or salt thereof.