Bacillus Alcohol-Degrading Composition for Gut-Based Liver Burden Reduction

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Solution Overview

Problem

There is a need for a composition that reduces the undesirable effects associated with alcohol ingestion, such as liver damage and hangover symptoms, by accelerating alcohol degradation in the body.

Innovation Solution

An alcohol degrading composition comprising one or more bacterial species of the Bacillus genus, rice bran, L-cysteine, and a high molecular weight low osmolality carbohydrate, such as dextrin, which creates a micro-environment in the gut to excrete enzymes that break down alcohol into carbon dioxide and water, bypassing liver metabolism and reducing alcohol absorption.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If alcohol is metabolized by the liver through conventional pathways, then alcohol is processed into acetaldehyde and acetic acid, but this causes liver damage, hangover symptoms, and toxic effects

Engineering Contradiction:

Improveliver damage and toxic effectsVSAvoidalcohol degradation rate

Core Design Contradiction:

Object-affected harmful factorsVSProductivity

Solution Approach 1:

The invention extracts the alcohol degradation function from the liver and relocates it to the gut by introducing Bacillus bacteria that produce alcohol-degrading enzymes. This separates the harmful liver metabolism pathway (producing acetaldehyde and acetic acid) from the beneficial degradation pathway (converting alcohol to carbon dioxide and water), thereby eliminating liver damage and hangover symptoms while maintaining effective alcohol processing.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The Bacillus bacteria act as intermediary agents between alcohol and the body's metabolic systems. These bacteria produce specific enzymes that mediate the conversion of alcohol into harmless carbon dioxide and water, bypassing the toxic liver metabolism pathway. The bacteria serve as a bridge that transforms alcohol degradation from a harmful process into a beneficial one.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Productivity

If L-cysteine is added to enhance alcohol degradation by Bacillus bacteria, then alcohol degradation efficiency increases, but the composition complexity increases

Engineering Contradiction:

Improvealcohol degradation efficiencyVSAvoidcomposition complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The invention modifies the chemical environment parameters by adding L-cysteine, which changes the gut's biochemical conditions to favor enhanced enzyme production by Bacillus bacteria. This parameter change (adding a specific amino acid) triggers a cascade effect that significantly boosts alcohol degradation efficiency without requiring complex structural modifications to the composition.

Inventive Principle:

Principle #35Parameter changes

3Productivity

If high molecular weight low osmolality carbohydrate is added to create a micro-environment in the gut, then enzyme excretion is enhanced, but the composition becomes more complex

Engineering Contradiction:

Improveenzyme excretion rateVSAvoidcomposition complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The high molecular weight low osmolality carbohydrate creates a localized micro-environment in the gut with specific physical and chemical properties. This local modification enhances enzyme excretion by Bacillus bacteria without requiring changes to the entire digestive system. The carbohydrate creates favorable local conditions (osmolality, viscosity, pH) that stimulate enzyme production and secretion.

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces blood and breath alcohol levels by accelerating alcohol degradation in the gut, thereby minimizing liver burden and associated health risks.

Implementation Method 1

L-cysteine can be used to increase alcohol degradation by one or more bacterial species of the Bacillus genus

Methodology Applied

Scientific EffectAlcohol degradation: Decomposition (biological)

Implementation Method 2

create a micro-environment in the gut that makes the microbial consortium of the compositions provided herein, upon resuscitation in the intestinal tract, excrete an enzyme cascade targeted towards short carbon chains, e.g. ethanol/alcohol

Methodology Applied

Scientific EffectEnzyme action: Enzyme

Implementation Method 3

L-cysteine can be used to increase alcohol degradation by one or more bacterial species of the Bacillus genus particularly when combined with a high molecular weight low osmolality carbohydrate

Methodology Applied

Scientific EffectMetabolic enhancement:

Implementation Method 4

The compositions described herein advantageously reduce the amount of alcohol absorption from the gut into the blood (and thus reduce the amount of alcohol that is processed by the liver)

Methodology Applied

Scientific EffectAbsorption reduction: Absorption (physical)

Data Source

PatentUS20250213626A1Alcohol degrading compositions and uses thereof

Publication Date: 2025.07.03 DE FAIRE MEDICAL AB

AI summary

The present invention provides an alcohol degrading composition comprising one or more bacterial species of the Bacillus genus, rice bran, L-cysteine and a high molecular weight low osmolality carbohydrate. Methods of using the composition are also provided herein.