Bacillus Coagulans Metabolite Hair Composition for 5α-Reductase Inhibition

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Solution Overview

Problem

Existing hair care solutions fail to effectively promote dermal papilla cell proliferation and inhibit 5α-reductase activity, leading to issues like hair loss and androgenic alopecia, with the beneficial effects of probiotics being strain-specific and not universally validated.

Innovation Solution

A composition containing a partially purified extracellular metabolite preparation from Bacillus coagulans is used to increase dermal papilla cell proliferation and inhibit 5α-reductase activity, formulated with pharmaceutically acceptable excipients for topical application.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional hair care solutions are used, then general hair care is provided, but they fail to effectively promote dermal papilla cell proliferation and inhibit 5α-reductase activity

Engineering Contradiction:

Improveeffectiveness in promoting dermal papilla cell proliferationVSAvoidstrain-specific beneficial effects not universally validated

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the specific parameter of probiotic strain selection from generic probiotics to the specifically identified Bacillus coagulans strain, which has been validated to effectively promote dermal papilla cell proliferation and inhibit 5α-reductase activity. This parameter change resolves the contradiction by providing a reliable, validated strain that overcomes the limitations of conventional solutions.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses extracellular metabolites produced by the validated Bacillus coagulans strain as the active ingredient in the composition. By copying and utilizing these specific metabolites rather than relying on the live organism itself, the invention achieves reliable and reproducible effects that can be universally applied regardless of strain variability.

Inventive Principle:

Principle #26Copying

2Reliability

If probiotics are used for hair care, then microbiome alteration and anti-fungal activity are achieved, but the beneficial effects are strain-specific and not universally validated

Engineering Contradiction:

Improvevalidated beneficial effects on hair growthVSAvoidcomplexity of strain identification and validation

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent extracts the beneficial extracellular metabolites from the Bacillus coagulans strain and uses them as the active ingredient in the composition. This extraction approach simplifies the solution by separating the validated effective components from the complex biological system, making the treatment more reliable and easier to standardize while maintaining the proven efficacy for promoting dermal papilla cell proliferation and inhibiting 5α-reductase activity.

Inventive Principle:

Principle #2Taking out (Extraction)

3Reliability

If 5α-reductase activity is not inhibited, then natural hair cycle continues, but overproduction of 5α-reductase leads to hair fall and androgenic alopecia

Engineering Contradiction:

Improveprevention of hair lossVSAvoidDHT overproduction

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent converts the harmful effect of 5α-reductase activity into a beneficial outcome by using Bacillus coagulans extracellular metabolites to selectively inhibit the enzyme. This inhibition prevents the conversion of testosterone to DHT, thereby preventing the harmful effects of DHT overproduction such as hair fall and androgenic alopecia, while maintaining natural physiological functions.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The extracellular metabolite from Bacillus coagulans enhances hair growth by increasing TGF-β2 and VEGF expression, inhibits 5α-reductase, and reduces DHT levels, offering therapeutic benefits for androgenic alopecia and seborrhoeic dermatitis.

Implementation Method 1

Both VEGF and TGF-β2 promote the proliferation of dermal papilla cells and thereby increase hair growth

Methodology Applied

Scientific EffectCell proliferation:

Implementation Method 2

Overproduction of 5α-reductase increases the conversion of testosterone to DHT in hair follicles, thereby disrupting the natural hair cycle leading to hair fall and development of androgenic alopecia

Methodology Applied

Scientific EffectEnzyme inhibition: Enzyme

Implementation Method 3

Vascular endothelial growth factor (VEGF) is essential for angiogenesis and vascular permeability and is responsible for maintaining proper vasculature around the hair follicle during the anagen growth phase

Methodology Applied

Scientific EffectAngiogenesis:

Data Source

PatentEP3634361B1Hair care compositions containing extracellular metabolite preparation from bacillus coagulans

Publication Date: 2026.01.28 SAMI LABS LTD

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AI summary

Disclosed are hair care compositions containing partially purified extracellular metabolite preparation from strains of Bacillus coagulans. Specifically, the uses of compositions containing extracellular metabolite preparation from a strain of Bacillus coagulans for increasing hair growth, inhibition of 5α-reductase and proliferation of follicle dermal papilla cells and in the management of androgenic alopecia, are disclosed.