Bacillus pumilus Ferment Extract for Adiponectin Increase

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Solution Overview

Problem

Current methods fail to effectively increase adiponectin levels and mitochondrial activity in muscle, leading to reduced muscular endurance and skin health benefits.

Innovation Solution

A ferment extract from a specific strain of Bacillus pumilus species (LMG P-28202) is used, containing peptidic and glucidic materials with a molecular weight less than 7000 Da, to increase adiponectin levels and stimulate mitochondrial activity, muscular endurance, and skin health.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional methods are used to increase adiponectin levels, then some baseline effect is achieved, but the levels are not sufficiently increased to provide optimal muscular endurance and skin health benefits

Engineering Contradiction:
Improveadiponectin levelsVSAvoideffectiveness of adiponectin increase
Core Design Contradiction:
Quantity of substanceVSProductivity

Solution Approach 1:

The patent changes the molecular weight parameter of the ferment extract components, specifically using components with molecular weight less than 7000 Da. This parameter change enables the extract to effectively increase adiponectin levels and provide the desired physiological effects that conventional methods fail to achieve.

Inventive Principle:
Principle #35Parameter changes

2Quantity of substance

If exercise is performed to increase adiponectin levels, then adiponectin levels increase and muscular endurance improves, but this requires significant physical activity that may not be feasible for all individuals

Engineering Contradiction:
Improveadiponectin levelsVSAvoidphysical activity requirement
Core Design Contradiction:
Quantity of substanceVSEase of operation

Solution Approach 1:

The patent uses ferment extract components as an intermediary substance that mediates the increase of adiponectin levels without requiring physical exercise. These low molecular weight components (less than 7000 Da) act as intermediaries to stimulate adiponectin production and provide the benefits normally associated with exercise-induced adiponectin increase.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Quantity of substance

If larger molecular weight ferment extract components are used, then more comprehensive nutritional content is provided, but the ability to increase adiponectin levels and stimulate mitochondrial activity is reduced

Engineering Contradiction:
Improvenutritional contentVSAvoidadiponectin increase effect
Core Design Contradiction:
Quantity of substanceVSReliability

Solution Approach 1:

The patent segments the ferment extract into components based on molecular weight, specifically isolating and using the fraction with molecular weight less than 7000 Da. This segmentation allows the extract to maintain comprehensive nutritional content while ensuring the presence of low molecular weight components that are critical for increasing adiponectin levels and stimulating mitochondrial activity.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The extract significantly increases adiponectin levels, mitochondrial activity, and muscular endurance, while also promoting skin health, wound healing, and collagen synthesis, enhancing overall physical and cosmetic benefits.

Implementation Method 1

A ferment extract from a specific strain of Bacillus pumilus species (LMG P-28202) is used, containing peptidic and glucidic materials with a molecular weight less than 7000 Da

Methodology Applied
Scientific EffectFermentation: Fermentation

Data Source

PatentEP3126011B1Ferment extract of a bacterial strain for the increase of adiponectin levels
Publication Date: 2020.07.29 LUBRIZOL ADVANCED MATERIALS INC

AI summary

Ferment extract of a bacterial strain for its use in treatment and/or care of the skin and/or muscles, as well as its cosmetic and/or dermopharmaceutical compositions. In particular, its use for muscular endurance, wound healing and skin firmness.