Bacillus Strain SOD Composition for Oxidative Stress in Fibrosis
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Solution Overview
Problem
Current treatments for fibrotic diseases such as pulmonary fibrosis and hepatic fibrosis are inadequate, with no effective drugs available to address oxidative stress and fibrosis progression.
Innovation Solution
A composition comprising Bacillus sp. strains, their spores, or superoxide dismutase (SOD) is administered to prevent or treat fibrotic diseases by reducing reactive oxygen species and ameliorating fibrosis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drugs are used to treat fibrotic diseases, then treatment is provided, but no effective drugs are available to address oxidative stress and fibrosis progression
Solution Approach 1:
The patent extracts and utilizes superoxide dismutase (SOD), a specific antioxidant enzyme, from Bacillus sp. strain to directly address oxidative stress in fibrotic diseases. This extraction of the key functional component (SOD) resolves the contradiction by providing a targeted therapeutic agent that specifically addresses oxidative stress, which conventional drugs fail to do.
Solution Approach 2:
The Bacillus sp. strain serves as a biological intermediary that produces and delivers superoxide dismutase to the affected tissues. This intermediary approach allows the treatment to effectively address oxidative stress while maintaining compatibility with the body's physiological systems, overcoming the limitations of conventional drugs.
2Object-affected harmful factors
If extracellular matrix accumulates in tissues causing fibrosis, then structural and functional problems occur, but the underlying cause may be unknown
Solution Approach 1:
The patent converts the harmful effect of oxidative stress (which contributes to ECM accumulation and fibrosis) into a beneficial therapeutic target. By administering superoxide dismutase to neutralize reactive oxygen species, the treatment transforms the harmful oxidative environment into a controlled therapeutic intervention, addressing both the harmful accumulation and the unknown etiology through mechanistic targeting.
3Object-affected harmful factors
If reactive oxygen species concentration is high in fibrotic diseases, then oxidative stress increases, but effective treatment to reduce ROS is unavailable
Solution Approach 1:
The Bacillus sp. strain performs self-service by producing and secreting superoxide dismutase as part of its metabolic function. This self-service capability of the bacterial strain provides a reliable and sustainable source of antioxidant enzyme treatment, resolving the contradiction by making effective ROS-reducing treatment naturally available through the biological system itself.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively ameliorates fibrosis by reducing oxidative stress, improving disease indicators, and enhancing survival rates in animal models, particularly in pulmonary fibrosis and nonalcoholic steatohepatitis.
Implementation Method 1
a composition comprising a Bacillus sp. strain expressing superoxide dismutase, a Bacillus sp. strain spore, and/or a superoxide dismutase (SOD), and a use thereof for preventing, ameliorating, or treating a fibrotic disease
Data Source
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AI summary
The present invention relates to a composition for the prevention, alleviation, or treatment of fibrotic diseases, containing a Bacillus species strain, a Bacillus species strain spore, each expressing superoxide dismutase, and/or superoxide dismutase. When orally administered, the composition allows the polypeptide with superoxide dismutase activity to remove reactive oxygen species in vivo, thus being helpful for the prevention, improvement, or treatment of fibrotic diseases such as pulmonary fibrosis or hepatic fibrosis.