Bacillus subtilis–Amino Acid Composition for Cell Rejuvenation
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Solution Overview
Problem
There is a need for a simple and reliable food supplement that can regulate cellular senescence and rejuvenate aged cells to young and healthy cells, addressing the issue of epigenetic age acceleration associated with age-related diseases.
Innovation Solution
A synbiotic composition comprising a probiotic Bacillus subtilis strain and dipeptides such as Glycine-Glutamine, Glycine-Glutamic acid, Alanine-Glutamine, or Alanine-Glutamic acid, optionally with additional components like curcuma extract and green tea extract, is administered to induce cell rejuvenation and reduce epigenetic age.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If aged cells accumulate in tissues, then tissue damage worsens and recovery ability decreases, but simply removing aged cells is not sufficient to prevent their re-accumulation and maintain long-term tissue health
Solution Approach 1:
The probiotic Bacillus subtilis and amino acid composition is administered in advance to prevent cellular senescence and epigenetic age acceleration before they lead to tissue damage. This preventive approach addresses the root cause of aging rather than merely treating symptoms after aged cells accumulate
Solution Approach 2:
The probiotic Bacillus subtilis and amino acid composition acts as an intermediary substance that mediates between environmental factors and cellular aging processes. It modifies histone post-translational modifications and epigenetic markers to counteract age acceleration caused by environmental confounders
2Reliability
If environmental confounders such as disease, stress, and malnutrition are present, then epigenetic age acceleration occurs and biological age increases faster than chronological age, but controlling these environmental factors through lifestyle changes is complex and difficult to implement consistently
Solution Approach 1:
The probiotic and amino acid composition serves as a pharmacological intermediary that directly counteracts epigenetic age acceleration without requiring complex lifestyle modifications. It provides a simplified, reliable intervention mechanism that acts independently of dietary habits, stress levels, or disease states
Solution Approach 2:
The composition directly modifies epigenetic parameters including DNA methylation patterns and histone post-translational modifications to reverse age acceleration. This changes the biological state of cells to a younger epigenetic profile, addressing the core problem at the molecular level rather than through behavioral changes
3Reliability
If a food supplement is designed to rejuvenate cells by modifying epigenetic markers and histone modifications, then cellular function improves and biological age decreases, but the complexity of the composition and mechanism increases
Solution Approach 1:
The invention uses a composite formulation combining probiotic Bacillus subtilis with specific amino acids (arginine, lysine, histidine, tryptophan, and/or phenylalanine). This composite approach leverages synergistic effects where the probiotic produces metabolites that work together with the amino acids to modify epigenetic markers and histone modifications, achieving rejuvenation through a coordinated multi-component system rather than a single complex mechanism
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces epigenetic age and rejuvenates cells by altering histone post-translational modifications, leading to improved cellular function and reduced age-related disease symptoms.
Implementation Method 1
The composition effectively reduces epigenetic age and rejuvenates cells by altering histone post-translational modifications
Data Source
AI summary
The present invention is related to composition for inducing rejuvenation of at least one cell, the composition comprising: —at least one probiotic Bacillus subtilis strain, and—at least one amino acid or peptide, wherein the amino acid is selected from glutamine, glutamic acid or salts thereof, and conjugated glutamine, and the peptide is an oligopeptide of 2-10 amino acid units in length, the amino acid units being natural amino acids, and at least one amino acid unit being a glutamine or glutamic acid unit.