Biological Control Agent and Insecticide Composition for Crop Protection

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Solution Overview

Problem

Current synthetic insecticides and fungicides are non-specific, toxic, and lead to resistance in pathogens, posing environmental and health concerns, while biological control agents have limited effectiveness and are not entirely satisfactory in controlling severe infections.

Innovation Solution

A composition comprising specific biological control agents like Bacillus pumilus, Bacillus subtilis AQ713, and Bacillus subtilis AQ30002 in synergistically effective amounts with insecticides such as Spirotetramat and Spiromesifen, applied simultaneously or sequentially to enhance control of insects, mites, nematodes, and phytopathogens, reducing overall damage and resistance formation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If synthetic insecticides and fungicides are used, then pest control effectiveness is improved, but environmental and health safety deteriorates due to toxicity and non-biodegradability

Engineering Contradiction:
Improvepest control effectivenessVSAvoidenvironmental and health safety
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines biological control agents (Bacillus subtilis, Bacillus pumilus) with synthetic insecticides and fungicides into a single composition, allowing the biological agents to reduce toxicity and environmental harm while the synthetic components maintain pest control effectiveness

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

Biological control agents serve as intermediaries that enhance the effectiveness of reduced amounts of synthetic pesticides, enabling lower application rates while maintaining control efficacy and reducing harmful residues

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If synthetic insecticides are repeatedly applied, then initial pest control is effective, but resistance development in pathogens occurs

Engineering Contradiction:
Improveinitial pest control effectivenessVSAvoidpathogen susceptibility
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent changes the mode of action parameter by introducing biological control agents with different mechanisms (parasitism, predation, competition) alongside synthetic pesticides, preventing resistance development through multi-target attack

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The composition uses composite action of biological control agents and synthetic pesticides, where the biological agents provide sustained control and resistance management while synthetic components deliver immediate knockdown effect

Inventive Principle:
Principle #40Composite materials

3Object-affected harmful factors

If biological control agents are used alone, then environmental safety is improved, but control effectiveness against severe infections deteriorates

Engineering Contradiction:
Improveenvironmental safetyVSAvoidcontrol effectiveness
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The biological control agents in the composition perform multiple functions: they provide base-level pest suppression, enhance the activity of synthetic pesticides, and reduce the required dosage of chemical components, thereby achieving both environmental safety and effective control

Inventive Principle:
Principle #6Universality (Multi-functionality)

4Loss of substance

If application rates of active compounds are reduced, then residues in crops are decreased, but control effectiveness may deteriorate

Engineering Contradiction:
Improvecrop residuesVSAvoidcontrol effectiveness
Core Design Contradiction:
Loss of substanceVSReliability

Solution Approach 1:

Biological control agents in the composition provide self-amplifying effects where they colonize the plant surface and continuously suppress pests over time, maintaining control effectiveness even at reduced application rates compared to synthetic pesticides alone

Inventive Principle:
Principle #25Self-service

Data Source

PatentEP2854532B1Compositions comprising a biological control agent and an insecticide
Publication Date: 2019.08.07 BAYER CROPSCIENCE AG
  • EP2854532B1 patent drawing

AI summary

The present invention relates to a composition comprising at least one biological control agent selected from the group consisting of Bacillus chitinosporus AQ746 (NRRL Accession No. B-21 618), Bacillus mycoldes AQ726 (NRRL Accession No, B-21664), Bacillus pumilus (NRRL Accession No, B-30087), Bacillus pumilus AQ717 (NRRL Accession No. B-21662), Bacillus sp. AQ175 (ATCC Accession No. 55608), Bacillus sp. AQ177 (ATCC Accession No. 55609), Bacillus sp. AQ178 (ATCC Accession No. 53522), Bacillus subtilis AQ743 (NRRL Accession No, B-21 665), Bacillus subtilis AQ713 (NRRL Accession No. B- 21661), Bacillus subtilis AQ153 (ATCC Accession No. 55614), Bacillus thuringiensis BD#32 (NRRL Accession No. B-21530), Bacillus thuringiensis AQ52 (NRRL Accession No. B- 21619), Muscodor albus 620 (NRRL Accession No, 30547), Muscodor roseus A3-5 (NRRL Accession No. 30548), Rhodococcus globerulus AQ719 (NRRL Accession No. B-21663), Streptomyces galbus (NRRL Accession No, 30232), Streptomyces sp. (NRRL Accession No. B-30145), Bacillus thuringiensis subspec. kurstaki BMP 123, Bacillus subtilis AQ30002 (NRRL Accession No. B-50421), and Bacillus subtilis AQ 30004 (NRRL Accession No. B- 50455) and/or a mutant of these strains having all the identifying characteristics of the respective strain, and/or a metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens and at least one insecticide selected from the group consisting of inhibitors of acetyl CoA carboxylase in a synergistlcally effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.