Bacillus Synbiotic Compositions for Gut Microbiota Modulation
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Solution Overview
Problem
Current probiotic strategies face challenges in effectively surviving and colonizing the gastrointestinal tract due to environmental factors, leading to insufficient impact on dysbiosis and a lack of modulation of gut microbiota composition.
Innovation Solution
A synbiotic preparation combining specific probiotic strains from the genus Bacillus, such as Bacillus subtilis, Bacillus licheniformis, and Bacillus amyloliquefaciens, with glutamine or its derivatives, which promotes favorable shifts in gut microbiota composition, particularly increasing Clostridium group XIVa members and reducing Clostridium group XI taxa.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If probiotic strains are administered to modify gut microbiota composition, then beneficial effects on host health are achieved, but the probiotics face poor survival and colonization due to gastrointestinal environmental factors
Solution Approach 1:
The patent uses spore-forming Bacillus strains as intermediaries that can withstand harsh gastrointestinal conditions. These spores act as protective carriers that survive stomach acid and bile, then germinate in the intestine to deliver probiotic benefits, thereby mediating between the harmful GI environment and the need for viable probiotics
Solution Approach 2:
The patent changes the physiological state of the probiotic organisms by using spore-forming Bacillus strains instead of vegetative cells. The spore form has fundamentally different resistance parameters to pH, bile, and digestive enzymes, allowing survival through the gastrointestinal tract while maintaining the ability to germinate and colonize in the intestine
2Productivity
If conventional probiotic strategies are used, then some health benefits are achieved, but there is insufficient impact on dysbiosis and lack of modulation of gut microbiota composition
Solution Approach 1:
The patent combines multiple Bacillus strains (B. subtilis, B. licheniformis, B. amyloliquefaciens) into a single synbiotic preparation, creating a synergistic effect that enhances the modulation of gut microbiota composition and addresses dysbiosis more effectively than single-strain probiotics
Solution Approach 2:
The patent creates a composite synbiotic preparation that integrates multiple probiotic Bacillus strains with prebiotic components, forming a multi-functional formulation that simultaneously supports probiotic survival and actively modulates gut microbiota composition to address dysbiosis
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of Bacillus strains with glutamine or its derivatives significantly increases the production of beneficial short-chain fatty acids like acetate and n-butyrate, while decreasing harmful iso-butyrate and iso-valerate levels, thereby enhancing gut health and microbiota balance.
Implementation Method 1
The combination of Bacillus strains with glutamine or its derivatives significantly increases the production of beneficial short-chain fatty acids like acetate and n-butyrate
Data Source
AI summary
A synbiotic preparation may include at least one probiotic strain and at least one amino acid or derivative thereof selected from glutamine, glutamic acid or salts thereof, conjugated glutamine, or oligopeptides of 2-10 amino acid units in length, wherein the amino acid units may be natural amino acids, and at least one amino acid unit being a glutamine or glutamic acid unit.