Bacterial Compositions for Food Allergy Immune Tolerance
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Solution Overview
Problem
Current therapeutics for treating allergies, particularly food allergies, are inadequate in effectively modulating immune responses and inducing tolerance or desensitization, with severe reactions ranging from mild to fatal.
Innovation Solution
Administering compositions comprising purified bacterial strains such as Clostridium bolteae, Anaerotruncus colihominis, and others, or specific 16S rDNA sequences, to modulate immune responses and induce tolerance or desensitization by suppressing IgE antibody production and Th2 immune responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional therapeutics are used to treat allergies, then treatment is provided, but the therapeutics are inadequate in effectively modulating immune responses and inducing tolerance or desensitization
Solution Approach 1:
The patent uses composite bacterial compositions containing multiple purified bacterial strains (e.g., Clostridium bolteae, Anaerotruncus colihominis, Sellimonas intestinales, Clostridium symbiosum, Blautia producta, Dorea longicatena, Erysipelotrichaceae bacterium, and Subdolinogranulum spp.) to create a synergistic therapeutic that effectively modulates immune responses and induces tolerance, overcoming the limitations of single-strain or conventional treatments
Solution Approach 2:
The patent changes the biological parameters of the treatment by introducing specific bacterial strains with particular 16S rDNA sequences that can alter the gut microbiome composition and function, thereby changing the immune system's response to allergens and inducing tolerance where conventional therapeutics failed
2Reliability
If antibiotic administration is used alone, then bacterial populations are modified, but immune tolerance and desensitization are not effectively induced
Solution Approach 1:
The patent merges antibiotic administration with subsequent administration of purified bacterial strains in a coordinated treatment protocol, where the antibiotic clears dysbiotic bacteria and the purified strains repopulate the gut microbiome with beneficial species that induce immune tolerance, achieving synergistic effects greater than either treatment alone
Data Source
AI summary
Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.