Pre-assembled Bag System for Biopharmaceutical Chromatography
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Solution Overview
Problem
Biological liquid treatment installations for purifying biopharmaceuticals, such as monoclonal antibodies and vaccines, face complexity and inefficiency due to the need for extensive cleaning and assembly of multi-component systems, especially under high pressure and with numerous components, which complicates the implementation of secure and effective treatment processes.
Innovation Solution
A bag-based system for biological liquid treatment by chromatography, featuring a network of conduits between connectors and flexible films, allowing for direct connection and easy manipulation of liquid flow paths without intermediate components, simplifying the treatment process and reducing the need for extensive cleaning and assembly.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If dedicated installations with stainless steel pipes and multiple components are used, then treatment reliability and security are improved, but device complexity and cleaning assembly operations increase
Solution Approach 1:
The patent integrates multiple separate components (conduits, connectors, valves) into a single pre-assembled bag system. The bag contains all necessary elements for chromatography treatment pre-connected together, eliminating the need for complex on-site assembly of multiple stainless steel components while maintaining treatment reliability.
Solution Approach 2:
The bag system serves multiple functions within a single component: it acts as a container, provides chromatography separation, includes integrated valves for flow control, and incorporates connectors for system integration. This multi-functionality reduces the overall number of components needed while maintaining comprehensive treatment capabilities.
2Ease of manufacture
If single-use components are implemented, then cleaning operations are eliminated, but assembly and verification complexity increases
Solution Approach 1:
By combining all necessary components (conduits, connectors, valves, chromatography media) into a single pre-assembled bag unit, the patent eliminates the need for complex assembly operations. The bag is manufactured as a complete system ready for use, requiring only connection to the treatment device without complex verification procedures.
3Adaptability or versatility
If numerous pipes and circuit components are used, then treatment functionality is improved, but assembly and operation simplicity deteriorates
Solution Approach 1:
The patent consolidates numerous pipes, connectors, and valves into a single integrated bag structure. The bag contains all necessary conduits and connections pre-arranged for chromatography treatment, providing full treatment functionality while requiring only a single connection operation to implement.
Data Source
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AI summary
The invention concerns a bag comprising a first conduit (13J), a second conduit (13K), the first section ( 13 J 1 ) of the first conduit (13J) and the first section (13K1 ) of the second conduit (13K) being opposite; a third conduit (13L) linking said first respective ends (13J2, 13K2) of said first respective sections (13J1, 13K1 ); a fourth conduit (13M) linking said second respective ends (13J3, 13K3) of said first respective sections (13J1, 13K1 ); a fifth conduit (13N) linking both said second end (13J3) of said first section ( 13 J 1 ) and said first end (13M1 ) of said fourth conduit (13M), and said fifth conduit (13N) linking both said first end (13K2) and said second end (13L2) of said third conduit (13L); said first conduit (13J) and said second conduit (13K) each being connected to a chromatography column connector (1 1 M).