Balloon Catheter Coating for Uniform Drug Release
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Solution Overview
Problem
Existing methods for coating balloon catheters with active ingredients are complex and expensive, leading to non-uniform medicament loading and release, which can cause vessel wall thickening and lumen constriction during minimally invasive procedures.
Innovation Solution
A method involving partial wetting of the balloon surface with a first active ingredient solution, followed by slow drying to form a lacquer-like layer, and subsequent wetting with a second saturated solution to increase brittleness and porosity, enhancing medicament release.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If microcapsules are used to enclose or glue active ingredient on balloon surface, then adhesion of active ingredient is improved, but manufacturing complexity and cost increase
Solution Approach 1:
The invention extracts the active ingredient directly from solution onto the balloon surface, eliminating the need for microcapsule structures. The active ingredient is applied in solution form and dried to form a coating, removing the complex microcapsule encapsulation and attachment steps while maintaining drug delivery functionality
Solution Approach 2:
The invention uses a solvent as an intermediary to apply the active ingredient. The solution acts as a medium that facilitates uniform distribution and adhesion of the active ingredient on the balloon surface, simplifying the process compared to direct microcapsule application
2Ease of manufacture
If active ingredient solution is applied and solvent evaporates, then active ingredient is located on surface, but adhesion and uniform release are insufficient
Solution Approach 1:
The invention applies a preliminary treatment to the balloon surface before active ingredient deposition. The surface is pre-treated with a solution that prepares it for subsequent active ingredient application, ensuring uniform absorption and distribution. This preliminary action creates optimal surface conditions for homogeneous medicament loading
Solution Approach 2:
The invention controls the evaporation rate and concentration parameters during the coating process. By managing the drying conditions and solution concentration, the process achieves uniform active ingredient distribution and adhesion, transforming the simple evaporation process into a precise coating method
3Quantity of substance
If coating is applied to balloon surface, then active ingredient release is achieved, but release uniformity and tissue contact are insufficient
Solution Approach 1:
The invention ensures that the active ingredient coating has consistent properties across the entire balloon surface. The application method creates uniform local conditions for drug release, ensuring that each area of the balloon delivers medication consistently when in contact with tissue
Solution Approach 2:
The invention employs a multi-step coating process with periodic application and drying cycles. This periodic action allows controlled deposition and uniform distribution of the active ingredient, ensuring homogeneous loading and consistent release characteristics across the coating
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method achieves a homogeneous, reproducible, and increased active ingredient release from the balloon catheter surface, improving tissue contact and reducing vessel constriction risks.
Implementation Method 1
the surface of the balloon that has been wetted with the first solution of an active ingredient should dry slowly
Implementation Method 2
a lacquer-like transparent active ingredient layer is produced that serves as a basis for a homogeneous and reproducible active ingredient loading
Implementation Method 3
The thus produced to surface has a chalk-like, in particular non-crystalline, consistency that enables an increased active ingredient removal by friction
Implementation Method 4
wetted with a second saturated solution of the active ingredient
Data Source
AI summary
The invention relates to a method for producing a bioactive surface on the balloon (3) of a balloon catheter (1). According to said method, the surface of the balloon (3) is at least partially wetted with a first solution of an active substance (8) and the section of the surface of the balloon (3) wetted with the first solution of an active substance (8) is then wetted with a second, saturated solution of the active substance (28). The invention further relates to a balloon (3) of a balloon catheter (1) the surface of which is at least partially coated with an active substance (11), the coating (11) being homogeneous and brittle in the entire coated region.