Ultrasonic Mist Inhaler Using Bamboo Capillary Atomization

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Solution Overview

Problem

Conventional mist inhaler devices, particularly ultrasonic nebulizers, are ineffective with viscous suspensions and tend to heat medications, destroying their therapeutic properties, and often deposit particles in the oropharyngeal region rather than deeper in the lungs, limiting their therapeutic efficacy.

Innovation Solution

An ultrasonic mist inhaler device that operates within a specific frequency range of 2.8MHz to 3.2MHz, using a capillary element made of bamboo fibers to produce mist without heating, ensuring efficient atomization and absorption, and utilizing a piezoelectric transducer to generate ultrasonic vibrations that create cavitation for efficient droplet formation and delivery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Temperature

If ultrasonic nebulizers operate at conventional frequencies (1 MHz to 1.7 MHz), then they can generate aerosol, but they heat the medication and destroy the molecules

Engineering Contradiction:
Improvemedication temperatureVSAvoidtherapeutic efficacy
Core Design Contradiction:
TemperatureVSReliability

Solution Approach 1:

The patent changes the operating frequency parameter from conventional 1-1.7 MHz to a higher range of 2.8-3.2 MHz. This parameter change allows the system to achieve effective atomization while avoiding the thermal degradation that occurs at lower frequencies, thus preserving medication integrity and therapeutic efficacy.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs mechanical vibration through ultrasonic transducers operating at 2.8-3.2 MHz to atomize the liquid medication. This high-frequency mechanical vibration creates cavitation bubbles that collapse to form fine aerosol droplets without significant heating, thereby maintaining medication stability while achieving effective pulmonary delivery.

Inventive Principle:
Principle #18Mechanical vibration

2Manufacturing precision

If conventional nebulizers are used, then they can deliver medication, but they deposit particles in the oropharyngeal region rather than deeper in the lungs

Engineering Contradiction:
Improveparticle size controlVSAvoidtherapeutic efficacy
Core Design Contradiction:
Manufacturing precisionVSReliability

Solution Approach 1:

The patent optimizes multiple parameters including ultrasonic frequency (2.8-3.2 MHz), liquid viscosity (1.05-1.412 Pa·s), and droplet size (0.25-0.5 microns) to achieve fine aerosolization. These parameter changes enable particles to bypass the oropharyngeal region and deposit deeper in the lungs, improving therapeutic efficacy while maintaining controllable particle characteristics.

Inventive Principle:
Principle #35Parameter changes

3Productivity

If ultrasonic nebulizers use high intensity vibrations, then they can atomize liquid, but they create cavitation that may damage the medication

Engineering Contradiction:
Improveatomization efficiencyVSAvoidcavitation damage
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent carefully selects and optimizes the ultrasonic frequency parameter (2.8-3.2 MHz) to achieve effective cavitation-based atomization while minimizing harmful effects. This specific frequency range provides sufficient energy for efficient aerosol generation while the short duration and controlled intensity prevent excessive cavitation damage to medication molecules.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The ultrasonic transducer operates with periodic high-frequency vibrations at 2.8-3.2 MHz, creating controlled cavitation cycles. This periodic action allows for efficient atomization while the brief duration of each cavitation cycle limits the cumulative damage to medication, balancing productivity with medication integrity.

Inventive Principle:
Principle #19Periodic action

4Temperature

If heating elements are used to produce vapour, then vapour can be generated, but the liquid is heated above boiling temperature which is not ideal for therapeutic delivery

Engineering Contradiction:
Improveliquid temperatureVSAvoidthermal degradation
Core Design Contradiction:
TemperatureVSObject-generated harmful factors

Solution Approach 1:

The patent replaces the thermal field (heating elements) with a mechanical field (ultrasonic vibration). Instead of heating the liquid to boiling temperature, high-frequency ultrasonic vibrations at 2.8-3.2 MHz directly mechanical atomize the liquid through cavitation, producing aerosol without significant thermal input and avoiding thermal degradation of therapeutic molecules.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device achieves higher efficiency in delivering therapeutic aerosols deeper into the lungs, reducing power consumption, and maintaining the integrity of medications, while the bamboo fibers provide antimicrobial properties and improved fluid retention, enhancing patient comfort and adherence.

Implementation Method 1

using a piezoelectric transducer to generate ultrasonic vibrations that create cavitation for efficient droplet formation and delivery

Methodology Applied
Scientific EffectPiezoelectric effect: Piezoelectric Effect

Implementation Method 2

During the low-pressure cycle, high-intensity ultrasonic waves create small vacuum bubbles or voids in the liquid. When the bubbles attain a volume at which they can no longer absorb energy, they collapse violently during a high-pressure cycle. This phenomenon is termed cavitation.

Methodology Applied
Scientific EffectCavitation: Cavitation

Implementation Method 3

ultrasonic mist inhaler devices for atomising a liquid comprising a therapeutic for inhalation by a user

Methodology Applied
Scientific EffectUltrasonic vibration: Ultrasonic Vibration

Implementation Method 4

using a capillary element made of bamboo fibers to produce mist without heating

Methodology Applied
Scientific EffectCapillary action: Capillary Action

Data Source

PatentEP4041003B1Mist inhaler devices
Publication Date: 2024.02.28 SHAHEEN INNOVATIONS HLDG LTD
  • EP4041003B1 patent drawingFigure 1
  • EP4041003B1 patent drawingFigure 2
  • EP4041003B1 patent drawingFigure 3

AI summary

A mist inhaler device (200) for generating a mist comprising a therapeutic for inhalation by a user. The device comprises a mist generator device (201) and a driver device (202). The driver device (202) is configured to drive the mist generator device (201) at an optimum frequency to maximise the efficiency of mist generation by the mist generator device (201).