Barb-Wired Silicon Micro Needle for Biopsy and Injection
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Solution Overview
Problem
Current biopsy devices are large, require significant reagents for analysis, cause patient pain and risk, and are complex to operate, while existing drug delivery systems cannot perform tissue sampling or targeted medication injection.
Innovation Solution
A barb-wired micro needle made of single crystalline silicon, miniaturized through silicon micromachining, which allows for simplified tissue sampling and medication injection via a fluid passage, with protrusion parts for tissue picking and extension parts for insertion and extraction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Volume of moving object
If a traditional biopsy device is used to pick tissue sample, then the tissue sample can be obtained, but the device size is large and requires large quantity of reagents for analysis
Solution Approach 1:
The invention divides the biopsy system into a miniaturized micro needle device for tissue sampling and a separate analysis system. The micro needle has a reduced volume design that can pick tissue samples with minimal intrusion, thereby reducing the overall device size and the quantity of reagents needed for subsequent analysis.
Solution Approach 2:
The invention extracts only the essential function of tissue sampling from the traditional large biopsy device, creating a dedicated micro needle device that performs solely the sampling function. This separation allows the sampling device to be miniaturized while the analysis can be performed on the extracted tissue sample with minimized reagent usage.
2Object-affected harmful factors
If a traditional biopsy device is used to pick tissue sample, then the tissue sample can be obtained, but the patient experiences pain and risk from medical treatment
Solution Approach 1:
The micro needle device incorporates a flexible extension part that can dynamically adapt to tissue characteristics during insertion. The device transitions from a rigid structure to a more compliant form that can navigate tissue layers with minimal resistance, reducing patient pain while maintaining reliable tissue sample acquisition capability.
Solution Approach 2:
The extension part of the micro needle is designed with flexible characteristics, allowing it to bend and adapt to the tissue structure during insertion. This flexibility reduces the mechanical stress and pain experienced by the patient while ensuring the device can reliably reach and sample the target tissue.
3Volume of moving object
If a microbiopsy/precision cutting device is used, then the tissue sample can be picked with miniaturization, but the biopsy procedures become very complex requiring skillful operator
Solution Approach 1:
The invention merges the tissue insertion function and sample picking function into a single integrated micro needle device. The micro needle itself serves both as the insertion instrument and the sample acquisition tool, eliminating the need for multiple separate操作步骤 and reducing procedural complexity while maintaining miniaturization.
Solution Approach 2:
The micro needle device is designed with multi-functionality, where the same device structure performs both insertion into tissue and picking of tissue samples. The extension part with protrusion parts provides universal functionality for both navigation through tissue and mechanical engagement with the target tissue for sampling.
4Adaptability or versatility
If a microbiopsy/precision cutting device is used, then the tissue sample can be picked with miniaturization, but additional function of injecting medicine into tissue cannot be performed
Solution Approach 1:
The micro needle device is designed with multi-functionality, integrating both tissue sampling and medicine injection capabilities into a single device. The hollow structure of the micro needle allows it to perform both mechanical sampling (through protrusion parts) and fluid delivery (through the hollow passage), thereby increasing versatility without proportionally increasing structural complexity.
Solution Approach 2:
The invention employs a nested structure where the hollow passage is embedded within the micro needle body, and the protrusion parts are integrated into the extension part. This nesting allows multiple functions (sampling and injection) to be accommodated within a compact structure, increasing versatility while controlling overall device complexity.
5Adaptability or versatility
If transcorneal drug-release system is used to inject drug, then the drug can be injected into skin, but the device cannot be inserted into body to pick tissue or inject drug into specific organ
Solution Approach 1:
The invention segments the device into a long, thin micro needle structure that can be inserted deep into the body to reach specific organs. The micro needle is divided into a main body part and an extension part, allowing it to navigate through tissue layers and reach target organs while maintaining a manageable overall structure that can be controlled during insertion.
Data Source
AI summary
Disclosed are a barb-wired single crystalline silicon micro needle and a biopsy method and a medicine injecting method using the same. The micro needle comprises a main body part, at least one extension part formed on a side surface of the main body part, and a protrusion part protruded from both side surfaces of the extension part. A medicine storage is formed on a surface of the main body part. A fluid passage is formed in the extension part and the main body part. It is easy to pick the tissue sample with the protrusion part just by inserting and extracting the extension part of the micro needle into and from the tissue for a biopsy. Therefore, the biopsy procedures can be simplified. In addition, the medicine in the storage can be injected into the tissue via the fluid passage.